Department of Cardiovascular Surgery, Nagasaki University Hospital, Nagasaki, Japan.
Ann Thorac Surg. 2012 May;93(5):e113-4. doi: 10.1016/j.athoracsur.2011.11.022.
A 73-year-old woman underwent both mitral and aortic valve replacements with porcine heart valve prostheses because of severe mitral regurgitation and severe aortic regurgitation. Ten months after surgery, maximal flow velocity of the aortic valve reached 4.6 m/sec and moderate mitral regurgitation was detected. Repeated mitral and aortic valve replacements with mechanical heart valves were performed. The excised mitral valve showed thinning of the 3 cusps, and 2 of them were perforated. There was pannus overgrowth on the flow surface of the porcine aortic valve. Histologic examination of the excised mitral valve revealed marked inflammatory changes with macrophages.
一位 73 岁女性因严重二尖瓣反流和严重主动脉瓣反流接受了二尖瓣和主动脉瓣置换术，使用的是猪心脏瓣膜假体。术后 10 个月，主动脉瓣最大流速达到 4.6m/s，发现中度二尖瓣反流。再次进行了二尖瓣和主动脉瓣置换术，使用了机械心脏瓣膜。切除的二尖瓣显示 3 个瓣叶变薄，其中 2 个瓣叶穿孔。猪主动脉瓣的血流面有赘生物生长。切除的二尖瓣组织学检查显示有明显的巨噬细胞炎症反应。
