Tübingen Ageing and Tumour Immunology Group, Center for Medical Research, University of Tübingen Clinical School, Waldhoernlestr. 22, D-72072 Tuebingen, Germany.
Curr Opin Immunol. 2012 Aug;24(4):507-11. doi: 10.1016/j.coi.2012.04.002. Epub 2012 Apr 27.
Dysregulated immunity, 'immunosenescence', in the elderly is thought to contribute to their increased susceptibility to infectious disease and to impact on mortality. Accepted hallmarks of human immunosenescence are low numbers and frequencies of naïve T cells and higher numbers and frequencies of memory T cells in the peripheral blood of the elderly compared to the young. The proportion of the population infected with CMV increases with age and markedly influences these parameters. Infection with this persistent β-herpesvirus may therefore indirectly impact on survival in the elderly. Recent evidence pertaining to this controversial proposal is reviewed here.
失调的免疫，即“免疫衰老”，被认为是老年人易感染传染病的原因之一，并对死亡率产生影响。公认的人类免疫衰老的特征是，与年轻人相比，老年人外周血中幼稚 T 细胞数量和频率较低，而记忆 T 细胞数量和频率较高。随着年龄的增长，人群中感染 CMV 的比例增加，这显著影响了这些参数。因此，这种持续性β疱疹病毒的感染可能间接影响老年人的生存。本文回顾了与这一争议性建议相关的最新证据。
