Govind Shelia, Lang Pierre Olivier, Bürkle Alexander, Moreno-Villanueva María, Franceschi Claudio, Capri Miriam, Bernard Jurgen, Weinberger Birgit, Grubeck-Loebenstein Beatrix, Fiegl Simone, Gonos Efstathios S, Sikora Ewa, Jansen Eugène, Dollé Martijn E T, Grune Tilman, Breusing Nicolle, Aspinall Richard
Medicines and Healthcare Products Regulatory Agency (MHRA), South Mimms Laboratories, Potters Bar, UK.
Genolier Clinic, Genolier, Switzerland.
Immun Ageing. 2024 Nov 29;21(1):84. doi: 10.1186/s12979-024-00490-9.
Decline in immune function with age has been studied extensively, but approaches to immune restoration have been hampered by the lack of simple methods of identifying individuals whose immune system is in decline. Our approach has been to identify individuals whose immune decline has led to a loss of control of common latent viral infections and their consequent reactivation. Viruses excreted in urine were detected and quantified and we believe this approach could provide a 'surrogate marker' for identifying immune compromised individuals. Here we report the detection of human herpes virus (HHV) 5, 6a, 6b and 7 in the urine of healthy individuals over a wide age range and their correlation with T cell receptor excision circle (TREC) data. The results did not show a clear correlation between TREC values and the detection of individual specific viruses or viral load values when measured singly. However, a correlation was found between low TREC values and the detection of several different human herpes viruses in the urine in males. We present evidence suggesting that for males, the detection of three or more different human herpes viruses in the urine could identify individuals with declining immune function as evidenced by their significantly lower TREC levels.
随着年龄增长免疫功能的衰退已得到广泛研究，但由于缺乏识别免疫系统正在衰退个体的简单方法，免疫恢复的方法受到了阻碍。我们的方法是识别那些免疫衰退导致对常见潜伏病毒感染失去控制并随之重新激活的个体。检测并量化尿液中排出的病毒，我们相信这种方法可为识别免疫功能受损个体提供一个“替代标志物”。在此我们报告在广泛年龄范围内健康个体尿液中人类疱疹病毒（HHV）5、6a、6b和7的检测情况以及它们与T细胞受体切除环（TREC）数据的相关性。单独测量时，结果并未显示TREC值与个体特异性病毒的检测或病毒载量值之间存在明显相关性。然而，在男性中发现低TREC值与尿液中几种不同人类疱疹病毒的检测之间存在相关性。我们提供的证据表明，对于男性而言，尿液中检测到三种或更多不同人类疱疹病毒可识别出免疫功能正在衰退的个体，其TREC水平显著降低即证明了这一点。
