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颅内毛细血管血管瘤:类似脑膜瘤的颅外轴内肿瘤病变。

Intracranial capillary hemangioma: extra-axial tumorous lesions closely mimicking meningioma.

机构信息

Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Republic of Korea.

出版信息

J Neurooncol. 2012 Aug;109(1):177-85. doi: 10.1007/s11060-012-0884-6. Epub 2012 Apr 29.

DOI:10.1007/s11060-012-0884-6
PMID:22544652
Abstract

Capillary hemangiomas are common tumorous lesions of the skin and soft tissue in infants. These lesions often involve internal organs and rarely develop in the intracranial space. Because of their rarity, clinical descriptions of intracranial capillary hemangioma have been anecdotal and have not provided a coherent understanding of these lesions. We report four cases of intracranial capillary hemangioma. Review of these 4 cases and 14 cases reported in the literature was undertaken to assess the influence of age, sex, location, clinical manifestation, treatment, and outcome. A significant difference was observed in age at diagnosis between sexes. The median age for male patients was 4.8 years (range 6 weeks to 20 years), and the median age for female patients was 22.5 years (range 4 months to 44 years). Approximately two-thirds of intracranial capillary hemangioma lesions develop in the vicinity of major venous sinuses, such as the cavernous/sphenoparietal sinus and the transverse sinus/torcular/superior sagittal sinus. This propensity for specific locations appears to be responsible for the symptom manifestation. The majority of the lesions also seem to be extra-axial in imaging and operative findings. Complete surgical resection provided excellent outcome, but incomplete resection led to recurrence. Capillary hemangioma should be considered in the diagnosis of extra-axial, contrast-enhancing lesions, especially in children and adolescents.

摘要

毛细血管血管瘤是婴儿皮肤和软组织中常见的肿瘤性病变。这些病变常累及内脏器官,很少发生在颅内。由于其罕见性,颅内毛细血管血管瘤的临床描述多为偶发病例,未能对这些病变形成连贯的认识。我们报告了 4 例颅内毛细血管血管瘤。对这 4 例病例和文献中报告的 14 例病例进行了回顾性分析,以评估年龄、性别、部位、临床表现、治疗和预后的影响。发现在诊断时的年龄在性别之间存在显著差异。男性患者的中位年龄为 4.8 岁(范围为 6 周至 20 岁),女性患者的中位年龄为 22.5 岁(范围为 4 个月至 44 岁)。大约三分之二的颅内毛细血管血管瘤病变发生在主要静脉窦附近,如海绵窦/蝶顶窦和横窦/窦汇/上矢状窦。这种对特定部位的倾向性似乎是导致症状表现的原因。大多数病变在影像学和手术发现中似乎也是位于脑外的。完全手术切除可获得良好的结果,但不完全切除可导致复发。对于脑外、对比增强病变,尤其是儿童和青少年,应考虑毛细血管血管瘤的诊断。

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