Division of Pediatric Neurology, Department of Pediatrics, Lady Hardinge Medical College and associated Kalawati Saran Children's Hospital, New Delhi 110001, India.
Indian J Pediatr. 2013 Mar;80(3):253-4. doi: 10.1007/s12098-012-0756-2. Epub 2012 Apr 28.
Primary amebic meningoencephalitis (PAME) is a rare condition, usually caused by free living motile amebae. These are universally fatal infections with very few survivors reported till now. The authors report a 25-d-old boy, the youngest survivor of Naegleria meningitis. The child was admitted with a diagnosis of partially treated meningitis. Cerebro-spinal fluid wet mount examination revealed free living motile amebae resembling Naegleria, which was further confirmed by culture. He was treated with amphoterecin B, rifampicin and fluconazole for 4 wk and ventriculoperitoneal shunt for obstructive hydrocephalous. At 8 mo follow up, child has survived with neurological sequlae.
原发性阿米巴脑膜脑炎(PAME)是一种罕见的疾病,通常由自由生活的运动性阿米巴引起。这些感染是普遍致命的,到目前为止,只有极少数幸存者的报道。作者报告了一名 25 天大的男孩,他是脑膜炎纳氏变形虫感染的最年轻幸存者。该患儿以部分治疗的脑膜炎入院。脑脊液湿片检查显示自由生活的运动性阿米巴类似于纳氏变形虫,培养进一步证实了这一点。他接受了两性霉素 B、利福平、氟康唑治疗 4 周,并进行了脑室-腹腔分流术以治疗梗阻性脑积水。在 8 个月的随访中,患儿存活但存在神经后遗症。