Street M L, White J W, Gibson L E
Department of Dermatology, Mayo Clinic, Rochester, MN 55905.
J Am Acad Dermatol. 1990 Nov;23(5 Pt 1):862-6. doi: 10.1016/0190-9622(90)70305-2.
Multiple eruptive keratoacanthoma of Witten and Zak is a rare disorder characterized by numerous small, eruptive tumors and larger, more typical keratoacanthomas. Affected patients have features of Grzybowski-type keratoacanthomas and Ferguson Smith type. Two patients with multiple keratoacanthomas were treated with oral retinoids. Both patients had hundreds of follicular papules on the trunk and extremities. Less common lesions included nodules with central horn-filled craters more characteristic of classic keratoacanthomas. Retinoid therapy resulted in regression of the larger, more typical keratoacanthomas in both patients. The small follicular keratoacanthomas remained unaffected. Thus oral retinoids are only partially beneficial for the treatment of the Grzybowski type or the Witten and Zak type of multiple eruptive keratoacanthomas.
维滕和扎克的多发性发疹性角化棘皮瘤是一种罕见的疾病，其特征是有许多小的、发疹性肿瘤以及较大的、更典型的角化棘皮瘤。受影响的患者具有格日博夫斯基型角化棘皮瘤和弗格森·史密斯型的特征。两名多发性角化棘皮瘤患者接受了口服维甲酸治疗。两名患者的躯干和四肢都有数百个毛囊丘疹。不太常见的损害包括有中央充满角栓的火山口样结节，更具经典角化棘皮瘤的特征。维甲酸治疗使两名患者中较大的、更典型的角化棘皮瘤消退。小的毛囊角化棘皮瘤未受影响。因此，口服维甲酸对格日博夫斯基型或维滕和扎克型多发性发疹性角化棘皮瘤的治疗仅部分有效。
