Centre de recherche du Centre Hospitalier de l'Université de Montréal, QC, Canada.
Cancer Causes Control. 2012 Jul;23(7):1039-46. doi: 10.1007/s10552-012-9970-5. Epub 2012 May 1.
Although there are few confirmed risk factors for prostate cancer (PCa), mortality rates are known to vary geographically across the United States. PCa mortality is higher among black and younger white men in a band of states spanning from Washington DC to Louisiana (the "PCa belt"). This study assessed the associations of birth and adult residence in the PCa belt with PCa mortality among black and white men and trends in these associations over time.
PCa-specific mortality rates in 1980, 1990, and 2000 for black and white men born in the continental US, aged 40-89, were calculated by linking national mortality records with population data based on birth state, state of residence at the census, race, and age. PCa belt (Washington DC, Virginia, North Carolina, South Carolina, Georgia, Mississippi, Alabama, and Louisiana) birth was cross-classified against PCa belt adult residence.
Black men born in the PCa belt had elevated PCa mortality in 1980, 1990, and 2000. Associations were independent of adult residence in the PCa belt. For example, in 2000, black men aged 65-89 who were born in the PCa belt but no longer lived there in adulthood had an odds ratio of 1.19 (1.14-1.24) for PCa mortality compared to black men born and residing outside the PCa belt. The PCa belt was not associated with PCa mortality among whites.
Geographically patterned childhood exposures, for example, differences in social or environmental conditions, or behavioral norms, may influence PCa mortality.
尽管前列腺癌（PCa）的已知危险因素很少，但据了解，其死亡率在美国各地存在地域差异。在从华盛顿特区到路易斯安那州的一片州内，黑人和较年轻的白人男性的 PCa 死亡率更高（“PCa 带”）。本研究评估了在 PCa 带出生和成年后居住与黑人和白人男性 PCa 死亡率的关联，以及这些关联随时间的变化趋势。
通过将国家死亡率记录与基于出生州、人口普查时的居住地、种族和年龄的人口数据相链接，计算了 1980 年、1990 年和 2000 年出生于美国大陆、年龄在 40-89 岁的黑人和白人男性的 PCa 特异性死亡率。将 PCa 带（华盛顿特区、弗吉尼亚州、北卡罗来纳州、南卡罗来纳州、佐治亚州、密西西比州、阿拉巴马州和路易斯安那州）出生与 PCa 带成年后居住情况进行交叉分类。
出生于 PCa 带的黑人男性在 1980 年、1990 年和 2000 年 PCa 死亡率较高。这些关联与成年后是否居住在 PCa 带无关。例如，在 2000 年，出生于 PCa 带但成年后不再居住在那里的 65-89 岁黑人男性，其 PCa 死亡率的比值比为 1.19（1.14-1.24），而出生于 PCa 带以外且居住在 PCa 带以外的黑人男性。PCa 带与白人男性的 PCa 死亡率无关。
地理模式的儿童期暴露，例如社会或环境条件或行为规范的差异，可能会影响 PCa 死亡率。
