自体骨髓基质细胞移植治疗犬急性脊髓损伤的安全性
Safety of autologous bone marrow stromal cell transplantation in dogs with acute spinal cord injury.
作者信息
Nishida Hidetaka, Nakayama Masanari, Tanaka Hiroshi, Kitamura Masahiko, Hatoya Shingo, Sugiura Kikuya, Harada Yasuji, Suzuki Yoshihisa, Ide Chizuka, Inaba Toshio
机构信息
Nakayama Veterinary Hospital, Nara, Japan.
出版信息
Vet Surg. 2012 May;41(4):437-42. doi: 10.1111/j.1532-950X.2011.00959.x. Epub 2012 Apr 30.
OBJECTIVE
To assess the feasibility and safety of transplantation of autologous bone marrow stromal cell (BMSC) in dogs with acute spinal cord injury (SCI).
STUDY DESIGN
An open-label single-arm trial.
ANIMALS
Dogs (n = 7) with severe SCI from T6 to L5, caused by vertebral fracture and luxation.
METHODS
Decompressive and stabilization surgery was performed on dogs with severe SCI caused by vertebral fracture and luxation. Autologous BMSCs were obtained from each dog's femur, cultured, and then injected into the lesion in the acute stage. Adverse events and motor and sensory function were observed for >1 year after SCI.
RESULTS
Follow-up was 29-62 months after SCI. No complications (eg, infection, neuropathic pain, worsening of neurologic function) were observed. Two dogs walked without support, but none of the 7 dogs had any change in sensory function.
CONCLUSIONS
Autologous BMSC transplantation is feasible and safe in dogs with acute SCI. Further studies are needed to determine the efficacy of this therapy.
目的
评估自体骨髓基质细胞（BMSC）移植治疗急性脊髓损伤（SCI）犬的可行性和安全性。
研究设计
开放标签单臂试验。
动物
7只因椎体骨折和脱位导致T6至L5严重SCI的犬。
方法
对因椎体骨折和脱位导致严重SCI的犬进行减压和稳定手术。从每只犬的股骨获取自体BMSC，进行培养，然后在急性期注入损伤部位。观察SCI后1年以上的不良事件以及运动和感觉功能。
结果
SCI后随访29至62个月。未观察到并发症（如感染、神经性疼痛、神经功能恶化）。2只犬无需支撑即可行走，但7只犬中无一例感觉功能有任何变化。
结论
自体BMSC移植治疗急性SCI犬是可行且安全的。需要进一步研究以确定该疗法的疗效。
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