自体骨髓单个核细胞移植与手术减压治疗一只慢性脊髓损伤犬
Autologous bone marrow mononuclear cell transplant and surgical decompression in a dog with chronic spinal cord injury.
作者信息
Tamura Katsutoshi, Harada Yasuji, Kunimi Maki, Takemitsu Hiroshi, Hara Yasushi, Nakamura Tatsuo, Tagawa Masahiro
机构信息
From the Department of Bioartificial Organs, Institute for Frontier Medical Sciences, Kyoto University, Kyoto; and the Aikouishida Animal Hospital, Kanagawa, Japan.
出版信息
Exp Clin Transplant. 2015 Feb;13(1):100-5. doi: 10.6002/ect.2013.0237. Epub 2014 Jun 25.
OBJECTIVES
In dogs with deep analgesia caused by acute spinal cord injury from thoracolumbar disk herniation, autologous bone marrow mononuclear cell transplant may improve recovery. The purpose of the present study was to evaluate autologous bone marrow mononuclear cell transplant in a dog that had paraplegia and deep analgesia caused by chronic spinal cord injury.
MATERIALS AND METHODS
Autologous bone marrow mononuclear cell transplant was performed in a dog having paraplegia and analgesia for 3 years that was caused by a chronic spinal cord injury secondary to Hansen type I thoracolumbar disk herniation. Functional recovery was evaluated with electrophysiologic studies and the Texas Spinal Cord Injury Scale.
RESULTS
Somatosensory evoked potentials were absent before transplant but were detected after transplant. Functional improvement was noted (Texas Spinal Cord Injury Scale: before transplant, 0; after transplant, 6). No adverse events were observed.
CONCLUSIONS
Autologous bone marrow mononuclear cell transplant into the subarachnoid space may be a safe and beneficial treatment for chronic spinal cord injury in dogs.
目的
在因胸腰椎间盘突出症导致急性脊髓损伤而处于深度镇痛状态的犬中，自体骨髓单个核细胞移植可能会促进恢复。本研究的目的是评估自体骨髓单个核细胞移植对一只因慢性脊髓损伤导致截瘫和深度镇痛的犬的治疗效果。
材料与方法
对一只因汉森I型胸腰椎间盘突出症继发慢性脊髓损伤而截瘫并镇痛3年的犬进行自体骨髓单个核细胞移植。通过电生理研究和德克萨斯脊髓损伤量表评估功能恢复情况。
结果
移植前体感诱发电位消失，但移植后可检测到。功能有所改善（德克萨斯脊髓损伤量表：移植前为0；移植后为6）。未观察到不良事件。
结论
蛛网膜下腔自体骨髓单个核细胞移植可能是治疗犬慢性脊髓损伤的一种安全有效的方法。
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