来自非类风湿性关节炎的贴壁滑膜细胞在长期培养中不会自发释放白细胞介素1β和前列腺素E2。
Adherent synovial cells from nonrheumatoid arthritis do not release interleukin 1 beta and prostaglandin E2 spontaneously in longterm culture.
作者信息
Goto M, Okamoto M, Sasano M, Yanagisawa S, Miyamoto T, Nishioka K, Nakamura K, Aotuka S, Kawakami N, Yokohari R
机构信息
Institute of Rheumatology, Tokyo Women's Medical College, Japan.
出版信息
J Rheumatol. 1990 Oct;17(10):1299-302.
Adherent synovial cells from both 13 patients without rheumatoid arthritis (RA) (gout, osteoarthritis and meniscal lesion) and 8 patients with RA consisted of dendritic cells, macrophage-like cells and fibroblast-like cells after cloning in a similar fashion as reported in our previous paper. All the adherent synovial cells from patients without RA did not release interleukin 1 (IL-1) beta and prostaglandin E2 (PGE2) spontaneously, while those cells released comparable amounts of IL-1 beta, but not PGE2 to RA cells after type II collagen stimulation. Only the synovial cells from RA, irrespective of morphology and cloning, released IL-1 beta and PGE2 without stimulation. Nonrheumatoid synovial cells may differ functionally from RA cells.
来自13名非类风湿性关节炎（RA）患者（痛风、骨关节炎和半月板损伤）和8名RA患者的贴壁滑膜细胞，经克隆后，与我们之前论文中报道的方式类似，均由树突状细胞、巨噬细胞样细胞和成纤维细胞样细胞组成。所有来自非RA患者的贴壁滑膜细胞均不会自发释放白细胞介素1（IL-1）β和前列腺素E2（PGE2），而这些细胞在II型胶原刺激后释放的IL-1β量与RA细胞相当，但不释放PGE2。仅来自RA的滑膜细胞，无论形态和克隆情况如何，在无刺激的情况下即可释放IL-1β和PGE2。非类风湿性滑膜细胞在功能上可能与RA细胞不同。
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