Toll 样受体 3 L412F 多态性与毛细支气管炎及毛细支气管炎后喘息婴幼儿的相关性研究。
Toll-like receptor 3 L412F polymorphisms in infants with bronchiolitis and postbronchiolitis wheezing.
机构信息
Seinäjoki Central Hospital, Seinäjoki, Finland. kirsi.nuolivirta@ fimnet.fi
出版信息
Pediatr Infect Dis J. 2012 Sep;31(9):920-3. doi: 10.1097/INF.0b013e31825aff25.
BACKGROUND
Innate immunity receptors play a critical role in host defense. In addition, the expression of Toll-like receptors (TLRs) has been connected to allergy and asthma.
AIMS
: To evaluate the association between the TLR3 L412F polymorphism and viral findings, clinical characteristics and subsequent wheezing in young infants with bronchiolitis.
METHODS
In all, 129 full-term infants hospitalized for bronchiolitis at age <6 months have been followed-up until the mean age of 1.5 years. Genotyping of the TLR3 L412F gene mutation was made by pyrosequencing.
RESULTS
TLR3 L412F gene polymorphism including the minor allele T was overrepresented (52%) in infants hospitalized with bronchiolitis. The presence of the major allele C as homozygous was associated with repeated postbronchiolitis wheezing (7.06, 95% confidence interval 2.30-21.66).
CONCLUSION
Preliminary evidence was found that TLR3 L412F gene polymorphism may be associated with bronchiolitis leading to hospitalization and postbronchiolitis wheezing.
背景
先天免疫受体在宿主防御中起着关键作用。此外，Toll 样受体（TLR）的表达与过敏和哮喘有关。
目的
评估 TLR3 L412F 多态性与病毒学发现、临床特征以及随后患有毛细支气管炎的婴幼儿喘息之间的关联。
方法
共纳入 129 名因毛细支气管炎而在 6 个月以下住院的足月婴儿，随访至平均年龄为 1.5 岁。通过焦磷酸测序进行 TLR3 L412F 基因突变的基因分型。
结果
包括次要等位基因 T 在内的 TLR3 L412F 基因多态性在因毛细支气管炎住院的婴儿中过度表达（52%）。主要等位基因 C 纯合子的存在与毛细支气管炎后反复喘息（7.06，95%置信区间 2.30-21.66）相关。
结论
初步证据表明，TLR3 L412F 基因多态性可能与导致住院和毛细支气管炎后喘息的毛细支气管炎有关。
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