Faculty of Dentistry, University of Barcelona, Centro Médico Teknon, Calle Vilana 12, 08022 Barcelona, Spain.
Med Oral Patol Oral Cir Bucal. 2012 Sep 1;17(5):e786-93. doi: 10.4317/medoral.18001.
Many therapies have been proposed for the management of neuropathic pain, and they include the use of different antiepileptic drugs. However, the lack of high quality studies indicates that results on the different neuropathic disorders under study do not recommend a particular drug treatment. This study makes a systematic review of the published literature on the use of several antiepileptic drugs to treat neuropathic pain, and has the objective of considering both its clinical characteristics and pharmacological use, which will depend on their level of scientific evidence and will follow the principles of evidence-based dentistry. The articles were stratified according to their scientific evidence using the SORT criteria (Strength of Recommendation Taxonomy), and it included those articles that only have level 1 or 2. Randomized clinical trials were stratified according to their level of quality using the JADAD scale, an instrument described by Jadad et al. (7). to assess the quality of clinical trials, while studies with a level below 3 were discarded. Recently, type A or B recommendations are given in favor or against the use of antiepileptic drugs to treat neuropathic pain on the basis of their scientific quality.
许多疗法已被提议用于治疗神经性疼痛，其中包括使用不同的抗癫痫药物。然而，由于缺乏高质量的研究，表明研究中不同神经性疾病的结果并不推荐特定的药物治疗。本研究对已发表的使用几种抗癫痫药物治疗神经性疼痛的文献进行了系统评价，目的是同时考虑其临床特征和药理学用途，这将取决于其科学证据水平，并遵循循证牙科的原则。根据 SORT 标准（推荐强度分类）对文章进行了科学证据分层，其中包括仅具有 1 级或 2 级证据的文章。根据 Jadad 等人描述的 Jadad 量表 (7) 对随机临床试验进行了质量分层，用于评估临床试验的质量，而低于 3 级的研究则被排除。最近，根据科学质量，对使用抗癫痫药物治疗神经性疼痛的方法进行了 A 型或 B 型推荐，以支持或反对使用。
