Pinelis Iu I, Tsybikov N N, Malezhik M S, Malezhik L P
Adv Gerontol. 2011;24(4):681-4.
Chronic generalized periodontitis in the old-aged patients is accompanied by high levels of the antibodies to HSP, sIgA, IgM, IgG hyperproduction; elevated concentrations of IL-8 and IL-1alpha and low content of IL-4 in saliva and blood. Local anti-inflammatory therapy of chronic periodontitis does not restore normal immunity status. Appearance of antibodies to HSP plays a role in immune reactions, which maintain chronic inflammation of periodontium.
老年患者的慢性广泛性牙周炎伴有高水平的热休克蛋白抗体、分泌型免疫球蛋白A、免疫球蛋白M、免疫球蛋白G过度产生；唾液和血液中白细胞介素-8和白细胞介素-1α浓度升高，白细胞介素-4含量降低。慢性牙周炎的局部抗炎治疗不能恢复正常免疫状态。热休克蛋白抗体的出现参与免疫反应，维持牙周组织的慢性炎症。
