Iordanishvili A K, Soldatov S V, Moskalev A V, Soldatova L N, Ryzhak G A
Adv Gerontol. 2011;24(3):515-20.
A comprehensive treatment with Likopid of chronic generalized parodontitis in 114 elderly and senile patients was carried out. The state of mechanisms of innate immunity (phagocytosis mechanisms) as well as the profile of proinflammatory cytokines was assessed. The effect of antibiotic-resistant strains of prior microflora on the combined therapy of patients of different age with chronic generalized parodontitis was studied. It is established that due to presence of various types of opportunistic pathogens in patients of different age with parodontitis using the prophylactic antibiotics for the empirical (to determine the antibiotic resistance), a combination of Metronidazole and Lincomycin with the mandatory appointment of immunomodulatory drugs for activation of monocyte-phagocytic system of the patient elderly is most advisable. Use of the drug , "Likopid" significantly improves the results of treatment the elderly and old patients with chronic generalized parodonthitis.
对114例老年和高龄慢性广泛性牙周炎患者采用利可派进行了综合治疗。评估了先天免疫机制（吞噬机制）状态以及促炎细胞因子谱。研究了先前微生物群的抗生素耐药菌株对不同年龄慢性广泛性牙周炎患者联合治疗的影响。已确定，由于不同年龄牙周炎患者存在各种机会性病原体，使用预防性抗生素进行经验性治疗（以确定抗生素耐药性），甲硝唑和林可霉素联合使用并强制为老年患者开具免疫调节药物以激活其单核吞噬系统最为可取。使用“利可派”药物可显著改善老年和高龄慢性广泛性牙周炎患者的治疗效果。
