Suga K, Tsuzuki T, Kawamura S, Seo K, Kubo T
Department of Urology, School of Medicine, Iwate Medical University, Morioka.
Nihon Heikatsukin Gakkai Zasshi. 1990 Feb;26(1):21-30. doi: 10.1540/jsmr1965.26.21.
Many workers have reported that ureteral peristaltic movement is controlled by the "so-called Pacemaker". But, in our recent studies, it was revealed that the existence of pacemaker is not always necessary for the peristaltic movement. In this study, we made isolated and non-isolated prototype models, using 18 mongrel dogs, to explore the influential factors on ureteral peristaltic discharge. Bilateral kidney and ureter were exposed transperitoneally. Unilateral upper urinary tract was prepared to preserve the pacemaker without renal blood supply, and contralateral one was prepared not to preserve the pacemaker by cutting at the proximal portion of the ureter. Vesico-ureteral reflux (VUR) was caused on these two models. A luminal pressure and ureteral electromyogram was recorded. In the result, there is spontaneous peristaltic discharges of the ureter which had the tendency to increase peristaltic frequency according to the increase of the luminal pressure. It was suggested that adequate expanding stimulation is the factor of peristaltic discharge to increase, and the peristaltic discharge under this condition propagates from upper to lower portion of the ureter.
许多工作人员报告称，输尿管的蠕动运动由“所谓的起搏器”控制。但是，在我们最近的研究中发现，蠕动运动并不总是需要起搏器的存在。在本研究中，我们使用18只杂种犬制作了离体和非离体的原型模型，以探讨影响输尿管蠕动排出的因素。经腹膜暴露双侧肾脏和输尿管。制备单侧上尿路以保留无肾血供的起搏器，对侧则通过在输尿管近端切断来制备不保留起搏器的模型。在这两种模型上引起膀胱输尿管反流（VUR）。记录腔内压力和输尿管肌电图。结果显示，输尿管存在自发性蠕动排出，其蠕动频率有随腔内压力增加而增加的趋势。提示适当的扩张刺激是蠕动排出增加的因素，在此条件下的蠕动排出从输尿管上部向下部传播。
