Wang Shaobai, Park Won Man, Gadikota Hemanth R, Miao Jun, Kim Yoon Hyuk, Wood Kirkham B, Li Guoan
a Bioengineering Laboratory, Department of Orthopaedic Surgery , Massachusetts General Hospital/Harvard Medical School , 55 Fruit St., GRJ 1215, Boston , MA 02114 , USA.
Comput Methods Biomech Biomed Engin. 2013;16(12):1278-86. doi: 10.1080/10255842.2012.668537. Epub 2012 May 3.
Evaluation of the loads on lumbar intervertebral discs (IVD) is critically important since it is closely related to spine biomechanics, pathology and prosthesis design. Non-invasive estimation of the loads in the discs remains a challenge. In this study, we proposed a new technique to estimate in vivo loads in the IVD using a subject-specific finite element (FE) model of the disc and the kinematics of the disc endplates as input boundary conditions. The technique was validated by comparing the forces and moments in the discs calculated from the FE analyses to the in vitro experiment measurements of three corresponding lumbar discs. The results showed that the forces and moments could be estimated within an average error of 20%. Therefore, this technique can be a promising tool for non-invasive estimation of the loads in the discs and may be extended to be used on living subjects.
评估腰椎间盘（IVD）上的负荷至关重要，因为它与脊柱生物力学、病理学和假体设计密切相关。椎间盘负荷的非侵入性估计仍然是一项挑战。在本研究中，我们提出了一种新技术，使用椎间盘的特定个体有限元（FE）模型和椎间盘终板的运动学作为输入边界条件来估计IVD的体内负荷。通过将有限元分析计算出的椎间盘内的力和力矩与三个相应腰椎间盘的体外实验测量值进行比较，对该技术进行了验证。结果表明，力和力矩的估计平均误差在20%以内。因此，该技术可能成为一种用于非侵入性估计椎间盘负荷的有前途的工具，并可能扩展到用于活体受试者。
