Medicine Service, Birmingham VA Medical Center and Department of Medicine, University of Alabama, Faculty Office Tower 805B, 510 20th Street S, Birmingham, AL 35294, USA.
BMC Med. 2012 May 2;10:44. doi: 10.1186/1741-7015-10-44.
Osteoarthritis (OA), the most common type of arthritis in the world, is associated with suffering due to pain, productivity loss, decreased mobility and quality of life. Systemic therapies available for OA are mostly symptom modifying and have potential gastrointestinal, renal, hepatic, and cardiac side effects. BMC Musculoskeletal Disorders recently published a study showing evidence of reparative effects demonstrated by homing of intra-articularly injected autologous bone marrow stem cells in damaged cartilage in an animal model of OA, along with clinical and radiographic benefit. This finding adds to the growing literature showing the potential benefit of intra-articular (IA) bone marrow stem cells. Other emerging potential IA therapies include IL-1 receptor antagonists, conditioned autologous serum, botulinum toxin, and bone morphogenetic protein-7. For each of these therapies, trial data in humans have been published, but more studies are needed to establish that they are safe and effective. Several additional promising new OA treatments are on the horizon, but challenges remain to finding safe and effective local and systemic therapies for OA.Please see related article: http://www.biomedcentral.com/1471-2474/12/259.
骨关节炎（OA）是世界上最常见的关节炎类型，与疼痛、生产力下降、活动能力下降和生活质量下降有关。OA 可用的全身治疗方法主要是症状改善，并有潜在的胃肠道、肾脏、肝脏和心脏副作用。BMC 肌肉骨骼疾病最近发表了一项研究，表明在 OA 动物模型中，关节内注射自体骨髓干细胞具有修复作用的证据，同时具有临床和影像学益处。这一发现增加了越来越多的文献表明关节内（IA）骨髓干细胞的潜在益处。其他新兴的潜在 IA 治疗方法包括白细胞介素-1 受体拮抗剂、条件自体血清、肉毒杆菌毒素和骨形态发生蛋白-7。对于这些治疗方法中的每一种，都已经在人类中发表了试验数据，但需要更多的研究来确定它们是安全有效的。几种有前途的新 OA 治疗方法即将出现，但仍需要找到安全有效的局部和全身 OA 治疗方法。请参阅相关文章：http://www.biomedcentral.com/1471-2474/12/259。
