基于 Diels-Alder 反应的 (-)- kainic 酸全合成。
A Diels-Alder-based total synthesis of (-)-kainic acid.
机构信息
Département de Chimie Moléculaire (SERCO) CNRS, UMR-5250, ICMG FR-2607, Université Joseph Fourier BP-53, 38041 Grenoble Cedex 9, France.
出版信息
J Org Chem. 2012 Jun 15;77(12):5286-96. doi: 10.1021/jo300608g. Epub 2012 May 29.
PMID:22551444
Abstract
An efficient synthesis of (-)-kainic acid, through a high-pressure-promoted Diels-Alder cycloaddition of a vinylogous malonate derived from 4-hydroxyproline, is described. The bicyclic adduct could be converted into the natural product with complete stereocontrol.
摘要
描述了通过 4-羟基脯氨酸衍生的乙烯基丙二酸酯的高压促进的 Diels-Alder 环加成反应高效合成（-）- kainic 酸。双环加成物可以通过立体控制完全转化为天然产物。
Zotero 插件