在西班牙，淋巴组织病理学的临床表现或组织学表现是否随着时间的推移而存在显著差异？
Are there any significant variations in the clinical or histological presentation of lymphoid pathologies over the course of time in Spain?
机构信息
Servicio de Oncología Médica, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain.
出版信息
Clin Transl Oncol. 2012 May;14(5):386-90. doi: 10.1007/s12094-012-0813-3.
INTRODUCTION
Little data is available concerning variations in the clinical characteristics of lymphoid neoplasms at presentation. We decided to investigate whether any variations in these characteristics had occurred in Spain during the last few years.
MATERIALS AND METHODS
The GOTEL group database is an archive of all new lymphoma cases, regardless of their histological subtype, diagnosed in the hospitals within the group. An analysis was made of all the records between 1 January 1999 and 1 January 2009. Though the number of hospitals submitting data has changed over the course of time, data were provided by 26 hospitals from 16 Spanish provinces.
RESULTS
A total of 3651 cases of lymphoma were recorded during this period. Grouped by clinical features, 42.8% (1561 patients) had low-grade lymphoma, 30.4% (1110 patients) intermediate-grade lymphoma and 15.2% (556 patients) Hodgkin's lymphoma; 208 patients had T lymphoma (5.7%), 111 patients high-grade lymphoma (3%) and 105 patients (2.9%) suffered lymphomas that were difficult to classify. A total of 6.3% of the diagnoses (231 patients) were made prior to 1999, 29.5% between 2000 and 2001, 25.7% between 2002 and 2003, 19.7% between 2004 and 2005, 11.2% between 2006 and 2007, and there were 200 entries from 2008 to the close of the study period, corresponding to 1.5% of the complete database. The median age at diagnosis was 60 (range 7-105 years), by percentiles: 25 corresponded to 44 years old, 50 to 60 years old and 75 to 71. Distribution by gender was 53.1% male and 46.9% female. An analysis was made of all the clinical variables collected, comparing their behaviour during the different diagnostic periods. The periods, gender, ECOG, stage, LDH, ß2 microglobulin, Hodgkin's or non- Hodgkin's type neoplasm, B lymphoma vs. Hodgkin's, NK or T, nodal or extra-nodal origin, median age at diagnosis and histological type by region of origin did not show any statistically significant differences in their distribution over the course of time.
CONCLUSION
In our experience, there are no significant variations in clinical presentation or histological type in lymphomas diagnosed over the course of time in Spain.
简介
关于淋巴肿瘤在初诊时的临床特征的变化，目前仅有少量数据。因此我们决定研究一下在过去几年里，西班牙是否出现了这些特征的变化。
材料与方法
GOTEL 组数据库是所有新诊断的淋巴瘤病例的档案，无论其组织学亚型如何，都包含在组内医院内。对 1999 年 1 月 1 日至 2009 年 1 月 1 日之间的所有记录进行了分析。虽然提交数据的医院数量随着时间的推移而变化，但有来自西班牙 16 个省的 26 家医院提供了数据。
结果
在此期间共记录了 3651 例淋巴瘤。根据临床特征分组，42.8%（1561 例）为低级别淋巴瘤，30.4%（1110 例）为中级别淋巴瘤，15.2%（556 例）为霍奇金淋巴瘤；208 例为 T 淋巴瘤（5.7%），111 例为高级别淋巴瘤（3%），105 例（2.9%）为难分类淋巴瘤。诊断前在 1999 年之前的占 6.3%（231 例），2000 年至 2001 年为 29.5%，2002 年至 2003 年为 25.7%，2004 年至 2005 年为 19.7%，2006 年至 2007 年为 11.2%，2008 年至研究结束时有 200 例，占完整数据库的 1.5%。中位诊断年龄为 60 岁（7-105 岁），按百分位数：25%对应 44 岁，50%对应 60 岁，75%对应 71 岁。性别分布为 53.1%为男性，46.9%为女性。分析了收集的所有临床变量，比较了它们在不同诊断期的变化。结果显示，不同诊断期、性别、ECOG、分期、LDH、β2 微球蛋白、霍奇金氏或非霍奇金氏肿瘤、B 细胞淋巴瘤与霍奇金氏淋巴瘤、NK 或 T 细胞、结内或结外起源、诊断时的中位年龄和组织学类型在不同时间的分布上没有统计学差异。
结论
根据我们的经验，在西班牙，随时间推移诊断出的淋巴瘤在临床表现或组织学类型上没有显著变化。
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