Girona Epidemiology Unit and Cancer Registry, Department of Health, Girona, Spain.
Ann Oncol. 2010 May;21 Suppl 3:iii90-96. doi: 10.1093/annonc/mdq088.
Attenuation of the epidemic increase in non-Hodgkin's lymphoma (NHL) incidence has recently been reported in the USA and Nordic European countries. After two decades of steadily increasing NHL, this study sought to ascertain whether a similar stabilisation might have taken place in Spain in recent years.
NHL cases were drawn from 13 population-based Spanish cancer registries with a record of at least 10 years of uninterrupted registration during the period 1975-2004. Overall and age-specific changes in incidence rates were evaluated using change-point Poisson models, which allow for accurate detection and estimation of trend changes.
A total of 21 335 NHL cases (11 531 male and 9804 female) were identified. Although overall age- and registry-adjusted incidence rates rose by 5.74% annually among men and 6.58% among women across the period 1975-95, a statistically significant change-point was nevertheless detected in both sexes in 1996, followed by stabilisation.
In Spain, NHL incidence levelled off in 1996 after a sharp increase during the 1970s and 1980s. This stabilisation is, partially at least, linked to the decrease in incidence of AIDS-related lymphomas among young adults.
最近有报道称，美国和北欧国家的非霍奇金淋巴瘤（NHL）发病率的流行增长已经得到了遏制。在 NHL 发病率持续增长二十年之后，本研究旨在确定近年来西班牙是否也出现了类似的稳定趋势。
本研究从 13 个基于人群的西班牙癌症登记处抽取 NHL 病例，这些登记处至少有 10 年不间断的登记记录，登记时间为 1975 年至 2004 年。使用具有准确检测和趋势变化估计功能的转折点泊松模型来评估总体发病率和年龄别发病率的变化。
共确定了 21335 例 NHL 病例（11531 例男性和 9804 例女性）。尽管在 1975 年至 1995 年期间，男性的年龄和登记处调整后的总体发病率每年增长 5.74%，女性的总体发病率每年增长 6.58%，但在两性中均在 1996 年检测到了统计学显著的转折点，随后发病率趋于稳定。
在西班牙，NHL 发病率在 20 世纪 70 年代和 80 年代急剧上升之后，于 1996 年趋于平稳。这种稳定在一定程度上与年轻人中与艾滋病相关的淋巴瘤发病率下降有关。
