Department of Psychiatry, Depression Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, #50 Irwon-dong, Gangnam-gu, Seoul 135-710, Republic of Korea.
J Psychiatr Res. 2012 Jul;46(7):966-72. doi: 10.1016/j.jpsychires.2012.04.006. Epub 2012 May 1.
A large amount of brain-derived neurotrophic factor (BDNF) is stored in the human platelets and only small amounts of it circulate in the plasma. However, a few studies have focused on platelet BDNF in patients with major depressive disorder (MDD) and childhood trauma. Our study population consisted of 105 MDD patients and 50 healthy controls. We used the mini-international neuropsychiatric interview (M.I.N.I.), the early trauma inventory self report-short form (ETISR-SF), as well as measured serum, plasma, and platelet BDNF at baseline, 1 month, and 3 month periods. There was a significant association between childhood trauma and platelet BDNF at baseline, 1 month, and 3 months, after adjusting for age, gender, education, body mass index, severity of depression, anxiety, alcohol consumption, and current stress. Conversely, plasma and serum BDNF did not have a significant association with childhood trauma. MDD patients revealed significantly higher levels of platelet BDNF in those with childhood trauma than in those without (t = 2.4, p = 0.018), and platelet BDNF was significantly higher in cases with sexual abuse on post-hoc analysis (p = 0.042). However, no significant differences were found in healthy controls, according to whether or not they had experienced childhood trauma. Platelet BDNF showed a significant correlation with severity of childhood trauma at baseline (r = 0.25, p = 0.012) and at 3 months (r = 0.38, p = 0.003) in MDD. In conclusion, platelet BDNF was significantly higher in MDD patients with childhood trauma than in those without, and it was correlated with severity of trauma.
大量脑源性神经营养因子（BDNF）储存在人类血小板中，只有少量在血浆中循环。然而，有一些研究集中在患有重度抑郁症（MDD）和儿童创伤的患者的血小板 BDNF 上。我们的研究人群包括 105 名 MDD 患者和 50 名健康对照者。我们使用迷你国际神经精神访谈（MINI）、早期创伤库存自我报告简短形式（ETISR-SF），以及在基线、1 个月和 3 个月期间测量血清、血浆和血小板 BDNF。在调整年龄、性别、教育程度、体重指数、抑郁严重程度、焦虑、饮酒和当前压力后，儿童期创伤与基线、1 个月和 3 个月时的血小板 BDNF 呈显著相关。相反，血浆和血清 BDNF 与儿童期创伤无显著相关性。MDD 患者的血小板 BDNF 明显高于无儿童期创伤的患者（t = 2.4，p = 0.018），且在后天分析中，有性虐待史的患者血小板 BDNF 明显更高（p = 0.042）。然而，在健康对照组中，根据他们是否经历过儿童期创伤，没有发现显著差异。血小板 BDNF 与基线时（r = 0.25，p = 0.012）和 3 个月时（r = 0.38，p = 0.003）儿童期创伤的严重程度呈显著相关性。总之，患有儿童期创伤的 MDD 患者的血小板 BDNF 明显高于无创伤的患者，且与创伤的严重程度相关。
