Ikejiri N
Department of Internal Medicine, Kurume University School of Medicine, Japan.
Kurume Med J. 1990;37(2):67-81. doi: 10.2739/kurumemedj.37.67.
Vitamin A-storing cells with lipid droplets and fluorescence characteristic of vitamin A were observed in the normal human and rat pancreas, using light, fluorescence, and electron microscopy. Vitamin A-storing cells in the normal human pancreas, as well as in the rat pancreas, were located predominantly in a perivascular area, and had lipid droplets with a fluorescence characteristic of vitamin A, Pancreatic vitamin A-storing cells had more numerous jipid droplets and more distinct fluorescence of vitamin A in vitamin A-loaded rats than in normal rats. In the rat, hepatic vitamin A-storing cells contained significantly more lipid droplets and had more distinct vitamin A fluorescence than pancreatic vitamin A-storing cells. Pancreatic sections from human subjects with chronic alcoholic pancreatitis revealed abundant vitamin A-storing cells surrounded by collagen fibers in an area of fibrosis. These results indicate that vitamin A-storing cells are widely distributed in the normal human and rat pancreas, although pancreatic vitamin A-storing cells have less storage capacity for vitamin A than do hepatic cells. Vitamin A-storing cells, as well as fibroblasts, may participate in the development of pancreatic fibrosis in chronic alcoholic pancreatitis, similar to the way hepatic vitamin A-storing cells participate in hepatic fibrosis.
利用光学显微镜、荧光显微镜和电子显微镜观察发现，在正常人体和大鼠的胰腺中存在含有脂滴且具有维生素A荧光特征的维生素A储存细胞。正常人体胰腺以及大鼠胰腺中的维生素A储存细胞主要位于血管周围区域，具有呈现维生素A荧光特征的脂滴。与正常大鼠相比，维生素A负荷大鼠的胰腺维生素A储存细胞含有更多的脂滴且维生素A荧光更明显。在大鼠中，肝脏维生素A储存细胞含有的脂滴明显多于胰腺维生素A储存细胞，且维生素A荧光更明显。来自患有慢性酒精性胰腺炎的人类受试者的胰腺切片显示，在纤维化区域有大量被胶原纤维包围的维生素A储存细胞。这些结果表明，维生素A储存细胞广泛分布于正常人体和大鼠的胰腺中，尽管胰腺维生素A储存细胞对维生素A的储存能力低于肝细胞。与肝脏维生素A储存细胞参与肝纤维化的方式类似，维生素A储存细胞以及成纤维细胞可能参与慢性酒精性胰腺炎中胰腺纤维化的发展。
