精神分裂症患者与健康对照者脑容量的拷贝数变异关联研究。
Association study of copy number variants with brain volume in schizophrenia patients and healthy controls.
机构信息
Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Huispostnummer A00.241, Heidelberglaan 100, 3584 CX, Utrecht, the Netherlands.
出版信息
Psychiatry Res. 2012 Dec 30;200(2-3):1011-3. doi: 10.1016/j.psychres.2012.04.007. Epub 2012 May 1.
Abstract
Schizophrenia patients have more copy number variations (CNVs) than healthy controls, and reduced brain volumes. Although this could suggest a causal relationship, we found no association between global CNV burden and three brain volume measures (on a MRI scan) in a sample of 173 schizophrenia patients and 176 healthy controls.
摘要
精神分裂症患者的拷贝数变异 (CNVs) 多于健康对照者，且大脑体积减小。虽然这可能表明存在因果关系，但在 173 名精神分裂症患者和 176 名健康对照者的样本中，我们并未发现全基因组 CNV 负担与三种大脑体积测量值（磁共振成像扫描）之间存在关联。
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