Department of Gastroenterology, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Madrid, Spain.
J Crohns Colitis. 2013 Mar;7(2):e61-5. doi: 10.1016/j.crohns.2012.04.005. Epub 2012 Apr 30.
Primary sclerosing cholangitis is a chronic progressive disorder which involves the medium size and large ducts in the intrahepatic and extrahepatic biliary tree. The great majority of cases have underlying inflammatory bowel disease, mainly ulcerative colitis. A higher risk of colorectal cancer has been described among ulcerative colitis patients with primary sclerosing cholangitis. Here we report a case of a primary sclerosing cholangitis in a young male with a newly diagnosed ulcerative colitis presenting with colonic dysplasia. Surveillance for colorectal cancer should be strongly recommended in this group of patients.
原发性硬化性胆管炎是一种慢性进行性疾病，涉及肝内和肝外胆管的中大型胆管。绝大多数病例有潜在的炎症性肠病，主要是溃疡性结肠炎。患有原发性硬化性胆管炎的溃疡性结肠炎患者中描述了更高的结直肠癌风险。在这里，我们报告了一例年轻男性的原发性硬化性胆管炎，该患者患有新诊断的溃疡性结肠炎，表现为结肠异型增生。应强烈建议该组患者进行结直肠癌监测。
