Laugesen Kim Bøgelund, Tøttrup Anders
Ønsbækvej 27, 8541 Skødstrup.
Ugeskr Laeger. 2014 Jan 20;176(4A):V07130441.
Ulcerative colitis (UC) is associated with an increased risk of colorectal cancer (CRC), but the risk is lower than previously estimated. In this review on the evidence of CRC risk in the UC population, we find that the effect of chemoprevention appears unproven. Surveillance should be offered in dedicated centres and restricted to subgroups with extensive disease, young age at unset, dysplastic findings or an additional diagnosis of primary sclerosing cholangitis. The use of random biopsies should be replaced by chromoendoscopy for targeting biopsies towards areas with abnormal appearance.
溃疡性结肠炎（UC）与结直肠癌（CRC）风险增加相关，但该风险低于先前估计。在本次关于UC人群CRC风险证据的综述中，我们发现化学预防的效果似乎未经证实。应在专门的中心进行监测，并仅限于患有广泛性疾病、发病年龄较轻、有发育异常表现或额外诊断为原发性硬化性胆管炎的亚组人群。应使用色素内镜检查取代随机活检，以便将活检靶向外观异常的区域。
