Skillen Annah, Currie Geoffrey M, Wheat Janelle M
Faculty of Science, Charles Sturt University, Wagga Wagga, Australia.
J Nucl Med Technol. 2012 Jun;40(2):99-103. doi: 10.2967/jnmt.111.098780. Epub 2012 May 2.
The visualization of hypermetabolic brown adipose tissue (BAT) on (18)F FDG PET lowers the efficacy of PET and has been linked with the environmental temperature of the patient before presentation. The objective of this paper is to investigate the effectiveness of thermal control on BAT and (18)F-FDG PET.
Three hundred patients undergoing (18)F-FDG PET were defined by 1 of 2 groups. Group A consisted of 150 consecutive patients from August to October 2009 (spring). Group B consisted of 150 consecutive patients from December to February 2010 (summer). In addition to normal preparation, group B received instructions to dress warmly and was warmed during the uptake period of their scan. Images were assessed for the presence of BAT. Standardized uptake value data were collected and compared.
BAT was present in 9.3% of patients; 15.3% of patients that were not warmed (group A) demonstrated BAT, and this was reduced to 3.3% in the group that underwent warming (group B) (P = 0.0005). BAT was more common in men (10.9%) than women (6.8%), and women responded better to warming. Younger patients were more likely to demonstrate BAT (P < 0.001). No significant relationship between BAT and height, weight, or body mass index was found. The most common site for BAT visualization was the cervical region (89%), followed by supraclavicular (75%), paravertebral (50%), suprarenal (21%) and paraaortic (7%) regions.
Thermal control for the reduction of BAT can achieve reductions in the incidence of BAT by as much as 78%. The reduction of BAT on PET images can reduce false-positive and false-negative results and minimize the need for rescanning.
在（18）F-FDG PET上可见的代谢活跃的棕色脂肪组织（BAT）会降低PET的效能，并且与患者检查前的环境温度有关。本文的目的是研究温度控制对BAT及（18）F-FDG PET的影响。
300例接受（18）F-FDG PET检查的患者分为两组。A组由2009年8月至10月（春季）的150例连续患者组成。B组由2010年12月至2月（夏季）的150例连续患者组成。除常规准备外，B组患者还收到穿暖和衣服的指示，并在扫描摄取期进行保暖。评估图像中BAT的存在情况。收集并比较标准化摄取值数据。
9.3%的患者存在BAT；未保暖组（A组）中15.3%的患者显示有BAT，而在接受保暖的组（B组）中这一比例降至3.3%（P = 0.0005）。BAT在男性（10.9%）中比女性（6.8%）更常见，且女性对保暖的反应更好。年轻患者更有可能显示有BAT（P < 0.001）。未发现BAT与身高、体重或体重指数之间存在显著关系。BAT可视化最常见的部位是颈部区域（89%），其次是锁骨上（75%）、椎旁（50%）、肾上腺（21%）和腹主动脉旁（7%）区域。
通过温度控制减少BAT可使BAT的发生率降低多达78%。PET图像上BAT的减少可减少假阳性和假阴性结果，并最大限度地减少再次扫描的必要性。
