Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences (NIRS), QST, 4-9-1 Anagawa, Inage-ku, Chiba-shi, Chiba 263-8555, Japan.
Department of Radiology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake-cho, Miyazaki-shi, Miyazaki 889-1692, Japan.
Contrast Media Mol Imaging. 2018 Feb 13;2018:4898365. doi: 10.1155/2018/4898365. eCollection 2018.
We retrospectively analyzed activated BAT visualization on FDG-PET/CT in patients with various conditions and TH levels to clarify the relationships between visualization of BAT on FDG-PET/CT and the effect of TH.
Patients who underwent clinical FDG-PET/CT were reviewed and we categorized patients into 5 groups: (i) thyroid hormone withdrawal (THW) group; (ii) recombinant human thyrotropin (rhTSH) group; (iii) hypothyroidism group; (iv) hyperthyroidism group; and (v) BAT group. A total of sixty-two FDG-PET/CT imaging studies in fifty-nine patients were performed. To compare each group, gender; age; body weight; serum TSH, FT3, and FT4 levels; and outside temperature were evaluated.
No significant visualization of BAT was noted in any of the images in the THW, rhTSH, hypothyroidism, and hyperthyroidism groups. All patients in the BAT group were in a euthyroid state. When the BAT-negative and BAT-positive patient groups were compared, it was noted that the minimum and maximum temperature on the day of the PET study and maximum temperature of the one day before the PET study were significantly lower in BAT-positive group than in all those of other groups.
Elevated TSH condition before RIT, hyperthyroidism, or hypothyroidism did not significantly impact BAT visualization of clinical FDG-PET/CT images.
我们回顾性分析了各种情况下和 TH 水平的 FDG-PET/CT 中激活 BAT 的可视化情况，以阐明 FDG-PET/CT 上 BAT 的可视化与 TH 作用之间的关系。
对接受临床 FDG-PET/CT 的患者进行了回顾性分析，并将患者分为 5 组：（i）甲状腺激素停药（THW）组；（ii）重组人促甲状腺激素（rhTSH）组；（iii）甲状腺功能减退组；（iv）甲状腺功能亢进组；和（v）BAT 组。对 59 例患者的 62 次 FDG-PET/CT 成像研究进行了比较。为了比较每组患者，评估了性别、年龄、体重、血清 TSH、FT3 和 FT4 水平以及环境温度。
在 THW、rhTSH、甲状腺功能减退和甲状腺功能亢进组的任何图像中均未观察到 BAT 的明显可视化。BAT 组的所有患者均处于甲状腺功能正常状态。当比较 BAT 阴性和 BAT 阳性患者组时，发现在 PET 研究当天的最低和最高温度以及 PET 研究前一天的最高温度在 BAT 阳性组明显低于其他组。
RIT 前的高 TSH 状态、甲状腺功能亢进或甲状腺功能减退不会显著影响临床 FDG-PET/CT 图像中 BAT 的可视化。
