Perkins Alan C, Mshelia Dahiru S, Symonds Michael E, Sathekge Mike
Radiological and Imaging Sciences, Medical Physics, Medical School Queen’s Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK.
Nucl Med Commun. 2013 Feb;34(2):168-74. doi: 10.1097/MNM.0b013e32835bbbf0.
The uptake of F-FDG in brown adipose tissue (BAT) may have important implications in understanding the pathophysiology of BAT and obesity. Because of the thermal implications of BAT uptake of F-FDG, this study aimed to contribute to existing knowledge by assessing patients scanned in a subtropical environment with particular reference to ethnicity.
A retrospective study was carried out to determine the prevalence and pattern of BAT uptake in patients undergoing F-FDG PET-CT imaging in a PET facility located in a subtropical climatic zone. Standardized uptake values were obtained for regions of BAT uptake of F-FDG, and the distribution pattern was assessed according to anatomical region, sex, age, BMI and ethnicity.
Following a reveiw of a total of 386 scans, 38 patients showed BAT uptake of F-FDG (9.85%), with the mass and activity of BAT being greater in women than in men (11.95 and 6.88%, respectively). BAT uptake of F-FDG in the neck/supraclavicular, axillary and mediastinal regions was greater in adults whose BMI was less than 18 kg/m. However, perirenal BAT activity was shown to be greater in obese individuals. The frequency of BAT uptake of F-FDG was 55% in winter as against 45% during summer (P<0.012). There was no statistical difference in BAT uptake between black and white patients.
This study shows the pattern and prevalence of BAT in patients in a subtropical environment. Although the average seasonal temperatures are higher in a subtropical climate, a seasonal variation in BAT expression was observed, although there were no differences with respect to patient ethnicity.
棕色脂肪组织（BAT）对F-FDG的摄取可能对理解BAT的病理生理学和肥胖症具有重要意义。由于BAT摄取F-FDG会产生热效应，本研究旨在通过评估在亚热带环境中扫描的患者，特别是考虑种族因素，为现有知识做出贡献。
进行了一项回顾性研究，以确定在位于亚热带气候区的PET设施中接受F-FDG PET-CT成像的患者中BAT摄取的患病率和模式。获取了F-FDG在BAT摄取区域的标准化摄取值，并根据解剖区域、性别、年龄、BMI和种族评估了分布模式。
在总共386次扫描的回顾中，38名患者显示出BAT对F-FDG的摄取（9.85%），女性BAT的质量和活性高于男性（分别为11.95%和6.88%）。BMI小于18 kg/m的成年人中，颈部/锁骨上、腋窝和纵隔区域的BAT对F-FDG的摄取更高。然而，肥胖个体的肾周BAT活性更高。冬季BAT摄取F-FDG的频率为55%，而夏季为45%（P<0.012）。黑人和白人患者之间的BAT摄取没有统计学差异。
本研究显示了亚热带环境中患者BAT的模式和患病率。尽管亚热带气候的平均季节温度较高，但观察到BAT表达存在季节性变化，尽管患者种族方面没有差异。
