慢性感染期间 HIV-1 从细胞毒性 T 淋巴细胞部分逃逸。
Partial escape of HIV-1 from cytotoxic T lymphocytes during chronic infection.
机构信息
Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, USA.
出版信息
J Virol. 2012 Jul;86(13):7459-63. doi: 10.1128/JVI.06724-11. Epub 2012 May 2.
Abstract
Viral mutational escape from CD8(+) cytotoxic T lymphocytes (CTLs) is typically considered to be a dichotomous process and uncommon during chronic HIV-1 infection. Ex vivo passaging of HIV-1 from persons with chronic infection, however, revealed the evolution of many fixed substitutions within and around CTL-targeted regions, with an associated increase in replicative capacity. This indicates an evolution of mutations during chronic HIV-1 infection that trade replicative fitness for incomplete evasion of CTLs, or "partial escape."
摘要
病毒从 CD8(+)细胞毒性 T 淋巴细胞 (CTL) 的突变逃逸通常被认为是一个二分过程，在慢性 HIV-1 感染中并不常见。然而，对慢性感染个体的 HIV-1 进行体外传代培养，揭示了 CTL 靶向区域内和周围的许多固定替代的演变，同时伴随着复制能力的增加。这表明在慢性 HIV-1 感染期间发生了突变进化，这些突变在复制适应性和不完全逃避 CTL 之间进行权衡，或者说是“部分逃逸”。
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