Jeffries Clark D, Johnson Charles R, Zhou Tong, Simpson Dennis A, Kaufmann William K
Renaissance Computing Institute, CB 3127, University of North Carolina at Chapel Hill, NC.
Gene Regul Syst Bio. 2012;6:55-66. doi: 10.4137/GRSB.S8476. Epub 2012 Apr 11.
This paper includes a conceptual framework for cell cycle modeling into which the experimenter can map observed data and evaluate mechanisms of cell cycle control. The basic model exhibits qualitative stability, meaning that regardless of magnitudes of system parameters its instances are guaranteed to be stable in the sense that all feasible trajectories converge to a certain trajectory. Qualitative stability can also be described by the signs of real parts of eigenvalues of the system matrix. On the biological side, the resulting model can be tuned to approximate experimental data pertaining to human fibroblast cell lines treated with ionizing radiation, with or without disabled DNA damage checkpoints. Together these properties validate a fundamental, first order systems view of cell dynamics. Classification Codes: 15A68.
本文包含一个细胞周期建模的概念框架，实验者可将观测数据映射到该框架中，并评估细胞周期控制机制。基本模型具有定性稳定性，这意味着无论系统参数的大小如何，其实例在所有可行轨迹都收敛到某一轨迹的意义上保证是稳定的。定性稳定性也可以用系统矩阵特征值实部的符号来描述。在生物学方面，所得模型可以进行调整，以近似与接受电离辐射处理的人类成纤维细胞系相关的实验数据，无论DNA损伤检查点是否失效。这些特性共同验证了细胞动力学的基本一阶系统观点。分类代码：15A68。
