铁代谢：与正常和异常红细胞生成的相互作用。
Iron metabolism: interactions with normal and disordered erythropoiesis.
机构信息
Department of Medicine and Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
出版信息
Cold Spring Harb Perspect Med. 2012 May;2(5):a011668. doi: 10.1101/cshperspect.a011668.
Abstract
Hemoglobinopathies and other disorders of erythroid cells are often associated with abnormal iron homeostasis. We review the molecular physiology of intracellular and systemic iron regulation, and the interactions between erythropoiesis and iron homeostasis. Finally, we discuss iron disorders that affect erythropoiesis as well as erythroid disorders that cause iron dysregulation.
摘要
血红蛋白病和其他红细胞疾病常与铁稳态异常有关。我们回顾了细胞内和全身铁调节的分子生理学，以及红细胞生成和铁稳态之间的相互作用。最后，我们讨论了影响红细胞生成的铁代谢紊乱以及导致铁调节异常的红细胞疾病。
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