Besharati Mohammad Reza, Shoja Mohammad Reza, Manaviat Masoud Reza, Kheirandish Maryam, Rad Maasome Zare
Department of Ophthalmology, Shahid Sadoughi University, Yazd-Iran.
Int J Ophthalmol. 2010;3(1):73-5. doi: 10.3980/j.issn.2222-3959.2010.01.17. Epub 2010 Mar 18.
To describe the involvement in relatives of keratoconus (KCN) patients with corneal topography map.
A total of 150 siblings of 300 eyes of 75 KCN patients referred to corneal clinic were studied and experienced complete slit-lamp, refraction examinations and topographic cornea maps provided by videophotoker-atography. ANOVA, Fisher exact and Chi-square tests performed to compare of results.
Of 150 siblings, 56% were female and 44% were male with average age of 21 (range 15-39) years. KCN and suspect KCN diagnosed in 12.3% and 6.6% respectively. The central keratometry (CK) was 46.5±4.51 dioptr (D) in KCN and 45.66±1.52D in suspect KCN. Inferior-superior value (I-S) was 3.51±2.5D in KCN and 1.56±1.22D in suspect KCN. In KCN condition the oval pattern was 67.6% (n=25) and Round pattern detected 32.4% (n=12). In suspect KCN these patterns detected 90% and 10% respectively. Refractive errors in KCN were -7.5 to +1.25 dioptr (-1.25±1.83), in suspect KCN 0.45 to -4.2 dioptr (-0.68±0.76) and in healthy group 2.75 to -7.5 dioptr (-0.6±1.12). Astigmatism was mild in 22.7%, moderate and sever astigmatism in 18.3% in KCN and suspect KCN CONCLUSION: Increasing KCN condition in healthy siblings of KCN patients shows require to screening plan to early diagnose and cautionly treatment of contact lens in these individuals.
通过角膜地形图描述圆锥角膜（KCN）患者亲属的患病情况。
对75例KCN患者300只眼睛的150名亲属进行研究，这些亲属均到角膜门诊就诊，并接受了完整的裂隙灯检查、验光检查以及视频光角膜照相术提供的角膜地形图检查。采用方差分析、Fisher精确检验和卡方检验来比较结果。
150名亲属中，56%为女性，44%为男性，平均年龄21岁（范围15 - 39岁）。分别有12.3%和6.6%被诊断为KCN和疑似KCN。KCN患者的中央角膜曲率（CK）为46.5±4.51屈光度（D），疑似KCN患者为45.66±1.52D。KCN患者的上下差值（I - S）为3.51±2.5D，疑似KCN患者为1.56±1.22D。在KCN患者中，椭圆形模式占67.6%（n = 25），圆形模式占32.4%（n = 12）。在疑似KCN患者中，这些模式分别占90%和10%。KCN患者的屈光不正为 - 7.5至 + 1.25屈光度（-1.25±1.83），疑似KCN患者为0.45至 - 4.2屈光度（-0.68±0.76），健康组为2.75至 - 7.5屈光度（-0.6±1.12）。KCN和疑似KCN患者中，22.7%为轻度散光，18.3%为中度和重度散光。结论：KCN患者健康亲属中KCN患病率增加，表明需要制定筛查计划，以便对这些个体进行早期诊断并谨慎使用隐形眼镜。
