Ling Shi-Qi, Liu Can, Li Wei-Hua, Xu Jian-Gang, Kuang Wen-Hui
Department of Ophthalmology, Guangzhou Women and Children's Medical Center, Guangzhou 510120, Guangdong Province, China.
Int J Ophthalmol. 2010;3(1):76-9. doi: 10.3980/j.issn.2222-3959.2010.01.18. Epub 2010 Mar 18.
To examine the relationship between corneal lymphangiogenesis and hemangiogenesis after keratoplasty.
Nineteen human corneas were obtained from 19 patients undergoing a second corneal transplantation in Zhongshan Ophthalmic Center in 2005. Blood and lymphatic vessels in human transplanted corneas were identified by lymphatic vessel endothelial receptor (LYVE-1) and platelet endothelial cell adhesion modecule-1 (PECAM-1) immunohistochemistry, and double enzyme-histochemistry; then the association of corneal blood vessel counting (BVC) with lymphatic vessel counting (LVC) was examined.
Corneal hemangiogenesis was present in 12 cases (63%), and lymphangiogenesis occurred in 5 cases (26%) human transplanted corneas. In addition, corneal lymphangiogenesis was only present in vascularized corneas. LVC was strongly and positively correlated with BVC (r=0.725, P<0.01).
Corneal lymphangiogenesis develops after keratoplasty and strongly associates with hemangiogenesis.
研究角膜移植术后角膜淋巴管生成与血管生成之间的关系。
2005年从中山大学中山眼科中心19例接受二次角膜移植的患者获取19个人类角膜。通过淋巴管内皮受体（LYVE-1）和血小板内皮细胞黏附分子-1（PECAM-1）免疫组化及双酶组织化学鉴定人类移植角膜中的血管和淋巴管；然后检测角膜血管计数（BVC）与淋巴管计数（LVC）的相关性。
12例（63%）人类移植角膜存在角膜血管生成，5例（26%）发生淋巴管生成。此外，角膜淋巴管生成仅出现在血管化角膜中。LVC与BVC呈强正相关（r=0.725，P<0.01）。
角膜移植术后角膜淋巴管生成，且与血管生成密切相关。
