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Uveal and capsular biocompatibility of two foldable acrylic intraocular lenses in patients with endogenous uveitis--a prospective randomized study.两种可折叠丙烯酸人工晶状体在内因性葡萄膜炎患者中的葡萄膜和囊膜生物相容性——一项前瞻性随机研究。
Graefes Arch Clin Exp Ophthalmol. 2008 Nov;246(11):1609-15. doi: 10.1007/s00417-008-0886-4. Epub 2008 Jul 19.
3
Biocompatibility of intraocular lens materials.人工晶状体材料的生物相容性。
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4
Uveal and capsular biocompatibility after implantation of sharp-edged hydrophilic acrylic, hydrophobic acrylic, and silicone intraocular lenses in eyes with pseudoexfoliation syndrome.在假性剥脱综合征眼中植入边缘锐利的亲水性丙烯酸酯、疏水性丙烯酸酯和硅酮人工晶状体后的葡萄膜和囊膜生物相容性
J Cataract Refract Surg. 2007 Aug;33(8):1414-8. doi: 10.1016/j.jcrs.2007.05.009.
5
Uveal and capsular biocompatibility of a single-piece, sharp-edged hydrophilic acrylic intraocular lens with collagen (Collamer): 1-year results.一体式、边缘锐利的含胶原蛋白亲水丙烯酸人工晶状体（科拉玛）的葡萄膜和囊膜生物相容性：1年结果
J Cataract Refract Surg. 2004 Jun;30(6):1254-8. doi: 10.1016/j.jcrs.2003.11.041.
6
Material properties of various intraocular lenses in an experimental study.一项实验研究中各种人工晶状体的材料特性。
Ophthalmologica. 2004 Jan-Feb;218(1):57-63. doi: 10.1159/000074568.
7
Uveal and capsular biocompatibility of hydrophilic acrylic, hydrophobic acrylic, and silicone intraocular lenses.亲水丙烯酸酯、疏水丙烯酸酯和硅酮人工晶状体的葡萄膜及囊膜生物相容性。
J Cataract Refract Surg. 2002 Jan;28(1):50-61. doi: 10.1016/s0886-3350(01)01122-1.
8
Intraocular lens biocompatibility.
J Cataract Refract Surg. 2002 Jan;28(1):1-2. doi: 10.1016/s0886-3350(01)01283-4.
9
Biocompatibility of intraocular lenses.
J Cataract Refract Surg. 2001 Feb;27(2):178-9. doi: 10.1016/s0886-3350(01)00742-8.
10
Improved biocompatibility of intraocular lenses by heparin surface modification: a 12-month implantation study in monkeys.
J Cataract Refract Surg. 1990 Mar;16(2):170-7. doi: 10.1016/s0886-3350(13)80726-2.

恒河猴中F-肝素修饰的人工晶状体

F-heparin modified intraocular lenses in Rhesus monkeys.

作者信息

Wang Gui-Qin, Gu Han-Qing, Yuan Jia-Qin, Sun Hui-Min, Xu Yan-Shan

机构信息

Department of Ophthalmology, the Naval General Hospital, Beijing 100048, China.

出版信息

Int J Ophthalmol. 2010;3(2):141-4. doi: 10.3980/j.issn.2222-3959.2010.02.11. Epub 2010 Jun 18.

DOI:10.3980/j.issn.2222-3959.2010.02.11
PMID:22553538
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3340764/
Abstract

AIM

In order to improve the biocompatibility of intraocular lenses (IOL), the polymethylmethacrylate (PMMA) IOL was modified with F-heparin.

METHODS

The PMMA IOL was modified with F ions and heparin by the technique of ion beam combined with low temperature and low pressure plasma. The monkeys (20 eyes) with cataract partly were randomly classified into 2 groups and implanted with PMMA IOL and modified IOL respectively for 180 days. All of the eyes were examined by slit-lamp microscope at postoperative 15, 30, 60, 90, 180 days. The extracted IOL was analyzed with computer image analysis, light microscope (LM) and scanning electron microscope (SEM) at postoperative 180 days.

RESULTS

The early inflammatory reactions postoperatively include anterior chamber exudation and aqueous cell count. The modified IOL group showed less than the non-modified IOL group. The late foreign body cell reaction that adhered to the surface of non-modified IOL was more predominant. The morphologic and pathological changes of posterior capsule opacification (PCO) in monkeys' eyes included fibrosis-type, pearl-type and soemmerring's ring. There was a significant difference between the two groups.

CONCLUSION

F-heparin modified IOL has good uveal and capsular biocompatibility.

摘要

目的

为提高人工晶状体（IOL）的生物相容性，采用氟肝素对聚甲基丙烯酸甲酯（PMMA）人工晶状体进行改性。

方法

采用离子束结合低温低压等离子体技术，用氟离子和肝素对PMMA人工晶状体进行改性。将部分患有白内障的猴子（20只眼）随机分为2组，分别植入PMMA人工晶状体和改性人工晶状体，观察180天。术后15、30、60、90、180天用裂隙灯显微镜检查所有术眼。术后180天，对取出的人工晶状体进行计算机图像分析、光学显微镜（LM）和扫描电子显微镜（SEM）分析。

结果

术后早期炎症反应包括前房渗出和房水细胞计数。改性人工晶状体组的反应少于未改性人工晶状体组。未改性人工晶状体表面的晚期异物细胞反应更为明显。猴眼后囊膜混浊（PCO）的形态学和病理学变化包括纤维化型、珍珠型和Soemmerring环型。两组之间存在显著差异。

结论

氟肝素改性人工晶状体具有良好的葡萄膜和囊膜生物相容性。