Wang Guiqin, Yuan Jiaqin, Sun Huimin, Gu Hanqing, Xu Yanshan, Dong Yali
International Intraocular Implant Training Center, Tianjin Medical University, Tianjin 300070, China (Email:
Zhonghua Yan Ke Za Zhi. 2002 Mar;38(3):154-6.
To study the biocompatibility of F-heparin surface modified intraocular lenses (IOLs) by observing cellular reaction on the surface of IOLs implanted into the rhesus monkeys' eyes.
Ten monkeys (20 eyes) were classified into two groups. PMMA IOLs and F-heparin modified IOLs were respectively implanted into 10 monkeys' eyes. The IOLs were examined with computer image analysis, light microscope (LM) and scanning electron microscope (SEM) at postoperative 180 and 360 days.
A few of adhered cells were on the surface of the central part of the IOL and more on the border of the IOL optics. The giant cells deposited on the surface occupied the largest area and the number of the macrophages was the greatest. The cells deposited on the surface of the IOLs in the F-heparin modified group were less than that in the non-modified group. In the modified group, there was fine granular proteinaceous membrane on the surface of the IOLs, but in the non-modified group there was fibrinous reticular proteinaceous membrane.
The biocompatibility of the F-heparin surface modified IOLs is better than that of non-modified PMMA IOLs.
