Huang Qi, Cheng George Pak-Man, Chiu Kin, Wang Gui-Qin
Department of Ophthalmology, Navy General Hospital of PLA, Beijing 100048; Department of Ophthalmilogy, Third Clinical Medical College of Southern Medical University, Guangzhou, Guangdong 510515, China.
Chin Med J (Engl). 2016 Jan 20;129(2):206-14. doi: 10.4103/0366-6999.173496.
This paper aimed to review the current literature on the surface modification of intraocular lenses (IOLs).
All articles about surface modification of IOLs published up to 2015 were identified through a literature search on both PubMed and ScienceDirect.
The articles on the surface modification of IOLs were included, but those on design modification and surface coating were excluded.
Technology of surface modification included plasma, ion beam, layer-by-layer self-assembly, ultraviolet radiation, and ozone. The main molecules introduced into IOLs surface were poly (ethylene glycol), polyhedral oligomeric silsesquioxane, 2-methacryloyloxyethyl phosphorylcholine, TiO 2 , heparin, F-heparin, titanium, titanium nitride, vinyl pyrrolidone, and inhibitors of cytokines. The surface modification either resulted in a more hydrophobic lens, a more hydrophilic lens, or a lens with a hydrophilic anterior and hydrophobic posterior surface. Advances in research regarding surface modification of IOLs had led to a better biocompatibility in both in vitro and animal experiments.
The surface modification is an efficient, convenient, economic and promising method to improve the biocompatibility of IOLs.
本文旨在综述目前关于人工晶状体（IOL）表面改性的文献。
通过在PubMed和ScienceDirect上进行文献检索，确定了截至2015年发表的所有关于IOL表面改性的文章。
纳入了关于IOL表面改性的文章，但排除了关于设计改性和表面涂层的文章。
表面改性技术包括等离子体、离子束、层层自组装、紫外线辐射和臭氧。引入IOL表面的主要分子有聚乙二醇、多面体低聚倍半硅氧烷、2-甲基丙烯酰氧乙基磷酰胆碱、TiO₂、肝素、F-肝素、钛、氮化钛、乙烯基吡咯烷酮和细胞因子抑制剂。表面改性可使晶状体表面更疏水、更亲水或具有亲水性前表面和疏水性后表面。IOL表面改性的研究进展在体外和动物实验中均带来了更好的生物相容性。
表面改性是提高IOL生物相容性的一种有效、便捷、经济且有前景的方法。
