Surface Modification of Intraocular Lenses.

OBJECTIVE

This paper aimed to review the current literature on the surface modification of intraocular lenses (IOLs).

DATA SOURCES

All articles about surface modification of IOLs published up to 2015 were identified through a literature search on both PubMed and ScienceDirect.

STUDY SELECTION

The articles on the surface modification of IOLs were included, but those on design modification and surface coating were excluded.

RESULTS

Technology of surface modification included plasma, ion beam, layer-by-layer self-assembly, ultraviolet radiation, and ozone. The main molecules introduced into IOLs surface were poly (ethylene glycol), polyhedral oligomeric silsesquioxane, 2-methacryloyloxyethyl phosphorylcholine, TiO 2 , heparin, F-heparin, titanium, titanium nitride, vinyl pyrrolidone, and inhibitors of cytokines. The surface modification either resulted in a more hydrophobic lens, a more hydrophilic lens, or a lens with a hydrophilic anterior and hydrophobic posterior surface. Advances in research regarding surface modification of IOLs had led to a better biocompatibility in both in vitro and animal experiments.

CONCLUSION

The surface modification is an efficient, convenient, economic and promising method to improve the biocompatibility of IOLs.