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CD4+PD-1+ T cells acting as regulatory cells during the induction of anterior chamber-associated immune deviation.在前房相关免疫偏离诱导过程中作为调节性细胞的CD4 + PD - 1 + T细胞。
Invest Ophthalmol Vis Sci. 2006 Oct;47(10):4444-52. doi: 10.1167/iovs.06-0201.
2
Induction of eye-derived tolerance does not depend on naturally occurring CD4+CD25+ T regulatory cells.眼源性耐受的诱导不依赖于天然存在的CD4+CD25+调节性T细胞。
Invest Ophthalmol Vis Sci. 2006 Mar;47(3):1047-55. doi: 10.1167/iovs.05-0110.
3
Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self.天然产生的表达Foxp3的CD25⁺CD4⁺调节性T细胞在对自身和非自身的免疫耐受中发挥作用。
Nat Immunol. 2005 Apr;6(4):345-52. doi: 10.1038/ni1178.
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Natural regulatory T cells and self-tolerance.天然调节性T细胞与自身耐受。
Nat Immunol. 2005 Apr;6(4):327-30. doi: 10.1038/ni1184.
5
Green T(R) cells.
Immunity. 2005 Mar;22(3):271-2. doi: 10.1016/j.immuni.2005.03.002.
6
Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma.分泌白细胞介素-10的调节性T细胞在过敏和哮喘中的潜在作用。
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GITR: a multifaceted regulator of immunity belonging to the tumor necrosis factor receptor superfamily.糖皮质激素诱导肿瘤坏死因子受体（GITR）：一种属于肿瘤坏死因子受体超家族的免疫多面调节因子。
Eur J Immunol. 2005 Apr;35(4):1016-22. doi: 10.1002/eji.200425818.
8
CD25(+)CD4(+) regulatory T cells exert in vitro suppressive activity independent of CTLA-4.CD25(+)CD4(+)调节性T细胞在体外发挥抑制活性，且不依赖于细胞毒性T淋巴细胞相关抗原4（CTLA-4） 。
Int Immunol. 2005 Apr;17(4):421-7. doi: 10.1093/intimm/dxh221. Epub 2005 Feb 21.
9
Dendritic cells loaded with stressed tumor cells elicit long-lasting protective tumor immunity in mice depleted of CD4+CD25+ regulatory T cells.负载应激肿瘤细胞的树突状细胞在耗尽CD4+CD25+调节性T细胞的小鼠中引发持久的保护性肿瘤免疫。
J Immunol. 2005 Jan 1;174(1):90-8. doi: 10.4049/jimmunol.174.1.90.
10
PD-1 ligands, negative regulators for activation of naive, memory, and recently activated human CD4+ T cells.PD-1配体，即未成熟、记忆及近期活化的人类CD4+ T细胞活化的负性调节因子。
Cell Immunol. 2004 Aug;230(2):89-98. doi: 10.1016/j.cellimm.2004.09.004.

CD4(+)CD25(+)调节性T细胞在前房相关免疫偏离形成中的作用。

Effect of CD4(+)CD25(+) regulatory T cells in the development of anterior chamber-associated immune deviation.

作者信息

Ji Shu-Xing, Yin Xiao-Lei, Yang Pei-Zeng

机构信息

Department of Ophthalmology, Daping Hospital, Third Military Medical University, Chongqing 400042, China.

出版信息

Int J Ophthalmol. 2011;4(1):19-25. doi: 10.3980/j.issn.2222-3959.2011.01.04. Epub 2011 Feb 18.

DOI:10.3980/j.issn.2222-3959.2011.01.04
PMID:22553601
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3340679/
Abstract

AIM

To investigate whether CD4(+)CD25(+) regulatory T (Treg) cells play a role in the development of anterior chamber-associated immune deviation (ACAID).

METHODS

The dynamic changes in the frequency of CD4(+)CD25(+) T cells, CD4(+)CD25(+) FoxP3(+) T cells and CD4(+)CD25(+) PD-1(+) T cells from spleens of mice with ACAID were analyzed by flow cytometry. Foxp3 mRNA expression in purified CD4(+)CD25(+) T cells was analyzed using real-time PCR. The suppressive effect of purified CD4(+)CD25(+) T cells on the proliferation of CD4(+)CD25(-) T cells was evaluated by [(3)H] thymidine incorporation. A blocking experiment was performed to further address the role of CD4(+)CD25(+) T cells in ACAID. The expression of IL-10 in purified CD4(+)CD25(+) T cells was evaluated by ELISA.

RESULTS

Increased frequencies of CD4(+)CD25(+) T cells, CD4(+)CD25(+) FoxP3(+) T cells and CD4(+)CD25(+) PD-1(+) T cells were observed in ACAID. The CD4(+)CD25(+) T cells from mice with ACAID showed enhanced suppressive effect on the proliferation of CD4(+)CD25(-) T cells. Treatment of BALB/c mice with anti-CD25 antibody after injection of OVA into the anterior chamber significantly inhibited the induction of ACAID. Furthermore, purified CD4(+)CD25(+) T cells from ACAID mice secreted IL-10.

CONCLUSION

Our results demonstrate that Treg cells are induced in the mice undergoing ACAID. These Treg cells may play a role in the development of ACAID.

摘要

目的

研究CD4(+)CD25(+)调节性T（Treg）细胞在前房相关免疫偏离（ACAID）的发生发展中是否发挥作用。

方法

采用流式细胞术分析ACAID小鼠脾脏中CD4(+)CD25(+) T细胞、CD4(+)CD25(+) FoxP3(+) T细胞和CD4(+)CD25(+) PD-1(+) T细胞频率的动态变化。利用实时PCR分析纯化的CD4(+)CD25(+) T细胞中Foxp3 mRNA的表达。通过[3H]胸苷掺入法评估纯化的CD4(+)CD25(+) T细胞对CD4(+)CD25(-) T细胞增殖的抑制作用。进行阻断实验以进一步探讨CD4(+)CD25(+) T细胞在ACAID中的作用。采用ELISA法评估纯化的CD4(+)CD25(+) T细胞中IL-10的表达。

结果

在ACAID中观察到CD4(+)CD25(+) T细胞、CD4(+)CD25(+) FoxP3(+) T细胞和CD4(+)CD25(+) PD-1(+) T细胞频率增加。来自ACAID小鼠的CD4(+)CD25(+) T细胞对CD4(+)CD25(-) T细胞的增殖显示出增强的抑制作用。在前房注射OVA后用抗CD25抗体处理BALB/c小鼠可显著抑制ACAID的诱导。此外，来自ACAID小鼠的纯化CD4(+)CD25(+) T细胞分泌IL-10。

结论

我们的结果表明，在经历ACAID的小鼠中诱导产生了Treg细胞。这些Treg细胞可能在ACAID的发生发展中发挥作用。