马来西亚糖尿病孕妇血清胰岛素样生长因子-I与视网膜病变的相关性
Correlation of serum insulin like growth factor-I with retinopathy in Malaysian pregnant diabetics.
作者信息
Adzura S, Muhaya M, Normalina M, Zaleha A M, Sharifa Ezat W P, Tajunisah I
机构信息
Department of Ophthalmology, Kulliyyah of Medicine, International Islamic University, Kuantan, Pahang, Malaysia.
出版信息
Int J Ophthalmol. 2011;4(1):69-72. doi: 10.3980/j.issn.2222-3959.2011.01.16. Epub 2011 Feb 18.
AIM
To study the association of serum insulin-like growth factor-I (IGF-I) with diabetic retinopathy.
METHODS
Serum IGF-1 levels were measured in 25 pregnant diabetic patients and 25 pregnant non-diabetic patients who were matched for age, ethnicity, parity and period of gestation. Fundus examination was performed in both groups at 28, 32 and 36 weeks of gestation.
RESULTS
The serum IGF-I level was significantly elevated in pregnant diabetics compared to pregnant non-diabetics (366±199μg/L vs 184±89μg/L, (P=0.0001) at 24 weeks, 535±251μg/L vs 356±89μg/L, (P=0.007) at 32 weeks and 404±166μg/L vs 264±113μg/L, (P=0.003) at 36 weeks of gestation). The pregnant diabetics with established diabetes had significantly higher IGF-1 level than gestational diabetes at 28, 32 and 36 weeks of gestation. The serum IGF-I level in pregnant diabetics with retinopathy was significantly higher than that in those without retinopathy at all periods of gestation.
CONCLUSION
Increased serum IGF-1 in pregnancy may increase the risks for retinopathy.
目的
研究血清胰岛素样生长因子-I（IGF-I）与糖尿病视网膜病变的关联。
方法
测定25例妊娠糖尿病患者和25例年龄、种族、胎次及孕周相匹配的妊娠非糖尿病患者的血清IGF-1水平。两组均在妊娠28、32和36周时进行眼底检查。
结果
与妊娠非糖尿病患者相比，妊娠糖尿病患者血清IGF-I水平显著升高（妊娠24周时：366±199μg/L对184±89μg/L，P = 0.0001；妊娠32周时：535±251μg/L对356±89μg/L，P = 0.007；妊娠36周时：404±166μg/L对264±113μg/L，P = 0.003）。在妊娠28、32和36周时，已确诊糖尿病的妊娠糖尿病患者的IGF-1水平显著高于妊娠期糖尿病患者。妊娠糖尿病合并视网膜病变患者在所有妊娠阶段的血清IGF-I水平均显著高于无视网膜病变者。
结论
孕期血清IGF-1升高可能增加视网膜病变风险。
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