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beta-Elemene, a novel plant-derived antineoplastic agent, increases cisplatin chemosensitivity of lung tumor cells by triggering apoptosis.β-榄香烯是一种新型的植物源抗肿瘤药物，通过诱导细胞凋亡增加肺肿瘤细胞对顺铂的化疗敏感性。
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Synthesis and in vitro anti-proliferative activity of beta-elemene monosubstituted derivatives in HeLa cells mediated through arrest of cell cycle at the G1 phase.β-榄香烯单取代衍生物的合成及其在HeLa细胞中的体外抗增殖活性，该活性通过使细胞周期阻滞在G1期介导。
Bioorg Med Chem. 2009 Feb 1;17(3):1118-24. doi: 10.1016/j.bmc.2008.12.040. Epub 2008 Dec 25.
4
[Effect of traditional Chinese medicine on quality of life and survival period in patients with progressive gastric cancer].[中药对进展期胃癌患者生活质量及生存期的影响]
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2008 Feb;28(2):105-7.
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Elemene for the treatment of lung cancer.榄香烯用于治疗肺癌。
Cochrane Database Syst Rev. 2007 Oct 17(4):CD006054. doi: 10.1002/14651858.CD006054.pub2.
6
[Posterior capsule opacification as a complication of the posterior chamber intraocular lens implantation].[后囊膜混浊作为后房型人工晶状体植入术的一种并发症]
Klin Oczna. 2004;106(1-2):19-22.
7
AKAP signaling complexes at the cytoskeleton.细胞骨架处的A激酶锚定蛋白（AKAP）信号复合物。
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A-kinase anchoring proteins: protein kinase A and beyond.A激酶锚定蛋白：蛋白激酶A及其他
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榄香烯体外抑制人晶状体上皮细胞增殖的机制

Mechanisms of inhibition of elemene on human lens epithelial cell proliferation in vitro.

作者信息

Hu Yan-Hong, Huang Xiu-Rong, Qi Ming-Xin, Hou Bu-Yuan

机构信息

Department of Ophthalmology, Second Affiliated Peoples Hospital of Fujian College of Traditional Chinese Medicine, Fuzhou 350003, Fujian Province, China.

出版信息

Int J Ophthalmol. 2011;4(3):255-8. doi: 10.3980/j.issn.2222-3959.2011.03.08. Epub 2011 Jun 18.

DOI:10.3980/j.issn.2222-3959.2011.03.08
PMID:22553656
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3340820/
Abstract

AIM

To study the effects of elemene (Ele) on proliferation and cell cycle of human lens epithelial cells B3 (HLE-B3) and the mechanisms of its signal transduction.

METHODS

Recombinant human basic fibroblast growth factor (rhbFGF) was used to induce proliferation of HLE-B3 cells, which were incubated with 80mg/L Ele for 24 hours. The inhibitory effects of Ele on the proliferation of HLE-B3 cells were evaluated by MTT method. The effect of Ele on HLE-B3 cell cycle was analyzed by flow cytometry(FCM). The expressions of protein kinase A (PKA) and protein kinase G (PKG) of HLE-B3 were also analyzed by FCM.

RESULTS

Ele altered the cell cycle of HLE-B3 and effectively inhibited HLE-B3 cell proliferation induced by rhbFGF. Ele up-regulated PKA and down-regulated the expression of PKG in HLE-B3 cell.

CONCLUSION

Ele inhibits HLE-B3 proliferation, making it an attractive potential agent in regimens to treat after-cataracts.

摘要

目的

研究榄香烯（Ele）对人晶状体上皮细胞B3（HLE - B3）增殖及细胞周期的影响及其信号转导机制。

方法

采用重组人碱性成纤维细胞生长因子（rhbFGF）诱导HLE - B3细胞增殖，将其与80mg/L榄香烯孵育24小时。采用MTT法评估榄香烯对HLE - B3细胞增殖的抑制作用。通过流式细胞术（FCM）分析榄香烯对HLE - B3细胞周期的影响。同时采用FCM分析HLE - B3中蛋白激酶A（PKA）和蛋白激酶G（PKG）的表达。

结果

榄香烯改变了HLE - B3的细胞周期，并有效抑制了rhbFGF诱导的HLE - B3细胞增殖。榄香烯上调HLE - B3细胞中PKA的表达并下调PKG的表达。

结论

榄香烯抑制HLE - B3增殖，使其成为治疗后发性白内障方案中一种有吸引力的潜在药物。