Terada Tadashi
Department of Pathology, Shizuoka City Shimizu Hospital, Shizuoka, Japan.
Appl Immunohistochem Mol Morphol. 2012 Mar;20(2):173-6. doi: 10.1097/pai.0b013e318229ea89.
Immunohistochemical studies of adenomatoid tumor (AT) are rare in the English literature. The author reports herein immunoprofile of AT of the female genital organs. The materials are 4 cases of AT of the uterus and 1 case of AT of the fallopian tube. The ages of the patients were 37, 41, 43, 45, and 56 years. The sizes of ATs were 0.8 cm, 1 cm, 1.5 cm, 2 cm, and 4 cm. The 4 ATs of the uterus were composed of tubules and smooth muscles, whereas 1 AT of the fallopian tube was composed only of tubules. Immunohistochemically, the ATs were consistently positive for pancytokeratin AE1/3+++, pancytokeratin CAM5.2 ++, cytokeratin (CK) 7 +++, CK8 +, CK18++, CK19++, calretinin +++, and D2-40 ++. Estrogen receptor (ER) and progesterone receptor (PgR) was positive in 4 of 5 cases. CK34βE12 was positive in 1 of 5 case. The Ki-67 labeling ranged from 0.2% to 3%. The smooth muscles in uterine ATs were positive for α-smooth muscle actin, ER, and PgR. The ATs were consistently negative for CK5/6, CK14, CK20, EMA, HMB45, vimentin, desmin, CD31, CD34, factor VIII-relatedantigen, S100 protein, p53, CD68, CDK4, MDM2, and Ber-EP4. These data indicate that ATs consistently express pancytokeratin AE1/3, pancytokeratin CAM5.2, CK7, CK8, CK18, CK19, calretinin, and D2-40, that some ATs express CK34βE12, ER, and PgR, that ATs show little proliferative activity, and that ATs were consistently negative for CK5/6, CK14, CK20, EMA, HMB45, vimentin, desmin, CD31, CD34, factor VIII-related antigen, S100 protein, p53, CD68, CDK4, MDM2, and Ber-EP4.
英文文献中关于腺瘤样瘤（AT）的免疫组织化学研究很少。本文作者报告了女性生殖器官AT的免疫表型。材料包括4例子宫AT和1例输卵管AT。患者年龄分别为37岁、41岁、43岁、45岁和56岁。AT的大小分别为0.8厘米、1厘米、1.5厘米、2厘米和4厘米。4例子宫AT由小管和平滑肌组成，而1例输卵管AT仅由小管组成。免疫组织化学检测显示，AT对全细胞角蛋白AE1/3呈强阳性（+++）、对全细胞角蛋白CAM5.2呈阳性（++）、对细胞角蛋白（CK）7呈强阳性（+++）、CK8呈阳性（+）、CK18呈阳性（++）、CK19呈阳性（++）、钙视网膜蛋白呈强阳性（+++）、D2-40呈阳性（++）。雌激素受体（ER）和孕激素受体（PgR）在5例中有4例呈阳性。CK34βE12在5例中有1例呈阳性。Ki-67标记指数范围为0.2%至3%。子宫AT中的平滑肌对α-平滑肌肌动蛋白、ER和PgR呈阳性。AT对CK5/6、CK14、CK20、EMA、HMB45、波形蛋白、结蛋白、CD31、CD34、因子VIII相关抗原、S100蛋白、p53、CD68、CDK4、MDM2和Ber-EP4始终呈阴性。这些数据表明，AT始终表达全细胞角蛋白AE1/3、全细胞角蛋白CAM5.2、CK7、CK8、CK18、CK19、钙视网膜蛋白和D2-40，一些AT表达CK34βE12、ER和PgR，AT增殖活性低，且AT对CK5/6、CK14、CK20、EMA、HMB45、波形蛋白、结蛋白、CD31、CD34、因子VIII相关抗原、S100蛋白、p53、CD68、CDK4、MDM2和Ber-EP4始终呈阴性。
