An immunohistochemical study of adenomatoid tumors of the uterus and fallopian tube.

Immunohistochemical studies of adenomatoid tumor (AT) are rare in the English literature. The author reports herein immunoprofile of AT of the female genital organs. The materials are 4 cases of AT of the uterus and 1 case of AT of the fallopian tube. The ages of the patients were 37, 41, 43, 45, and 56 years. The sizes of ATs were 0.8 cm, 1 cm, 1.5 cm, 2 cm, and 4 cm. The 4 ATs of the uterus were composed of tubules and smooth muscles, whereas 1 AT of the fallopian tube was composed only of tubules. Immunohistochemically, the ATs were consistently positive for pancytokeratin AE1/3+++, pancytokeratin CAM5.2 ++, cytokeratin (CK) 7 +++, CK8 +, CK18++, CK19++, calretinin +++, and D2-40 ++. Estrogen receptor (ER) and progesterone receptor (PgR) was positive in 4 of 5 cases. CK34βE12 was positive in 1 of 5 case. The Ki-67 labeling ranged from 0.2% to 3%. The smooth muscles in uterine ATs were positive for α-smooth muscle actin, ER, and PgR. The ATs were consistently negative for CK5/6, CK14, CK20, EMA, HMB45, vimentin, desmin, CD31, CD34, factor VIII-relatedantigen, S100 protein, p53, CD68, CDK4, MDM2, and Ber-EP4. These data indicate that ATs consistently express pancytokeratin AE1/3, pancytokeratin CAM5.2, CK7, CK8, CK18, CK19, calretinin, and D2-40, that some ATs express CK34βE12, ER, and PgR, that ATs show little proliferative activity, and that ATs were consistently negative for CK5/6, CK14, CK20, EMA, HMB45, vimentin, desmin, CD31, CD34, factor VIII-related antigen, S100 protein, p53, CD68, CDK4, MDM2, and Ber-EP4.