Phadiatop 检测在评估运动员呼吸道过敏症状易感性中的作用。

Phadiatop testing in assessing predisposition to respiratory tract symptoms of allergic origin in athletes.

机构信息

College of Health Sciences, University of KwaZulu-Natal, Durban.

出版信息

S Afr Med J. 2012 Mar 22;102(5):309-11. doi: 10.7196/samj.5405.

DOI:10.7196/samj.5405

PMID:22554340

Abstract

OBJECTIVES

To validate the use of the Phadiatop test as a predictor of allergy-associated respiratory tract symptoms (RTS) in trail runners.

METHODS

The incidence of self-reported RTS was documented in 16 runners for 31 days and related to the Phadiatop status and circulating markers of allergic responses (changes in concentrations of serum IgE (sIgE), differential leucocyte counts) at 8 time points before, during and after a 3-day 95 km trail run.

RESULTS

Twelve (75%) athletes, of whom 7 (58%) were Phadiatoppositive, presented with post-race RTS. A peak sIgE concentration >100 IU/ml accompanied RTS in only 4 (57%) of the symptomatic Phadiatop-positive subjects. There was no significant difference between the eosinophil and basophil concentrations of the positive and negative groups (p>0.05). One Phadiatop-negative subject presented with RTS as well as a peak sIgE concentration >100 IU/ml.

CONCLUSION

The Phadiatop assay does not accurately predict the development of post-exercise RTS of allergic origin in trail runners.

摘要

目的

验证 Phadiatop 试验作为预测越野跑运动员与过敏相关的呼吸道症状（RTS）的指标的有效性。

方法

16 名跑步者在 31 天内记录了自我报告的 RTS 发生率，并将其与 Phadiatop 状态以及在 3 天 95 公里越野跑前后 8 个时间点的循环过敏反应标志物（血清 IgE（sIgE）浓度变化、白细胞分类计数）相关联。

结果

12 名（75%）运动员出现赛后 RTS，其中 7 名（58%）为 Phadiatoppositive。仅在 4 名（57%）有症状的 Phadiatop 阳性受试者中，sIgE 浓度峰值>100 IU/ml 伴随 RTS。阳性组和阴性组的嗜酸性粒细胞和嗜碱性粒细胞浓度无显著差异（p>0.05）。1 名 Phadiatop 阴性受试者出现 RTS 以及 sIgE 浓度峰值>100 IU/ml。