Department of Applied Bioscience, Laboratory for Immune Cell-Based Therapy, CHA University, Gyeonggi-do 463-836, Republic of Korea.
Cancer Lett. 2012 Nov 1;324(1):58-65. doi: 10.1016/j.canlet.2012.04.024. Epub 2012 Apr 30.
Dendritic cell (DC)-mediated immunotherapy has not been as effective as expected for most solid tumors. This study demonstrates immune responses against solid tumors mediated by DCs charged with photodynamic therapy (PDT)-induced tumor lysates, which contain the heat shock protein (HSP) 70. PDT tumor lysate-pulsed DC (PDT-DC) inhibited the growth of mammary EMT6 tumors to a greater extent than freeze/thawed tumor lysate-pulsed DC (FT-DC) or PDT tumor lysates. PDT-DC also showed significant anti-tumor effects against fully-established (i.e., late-stage) solid tumors. Taken together, these results suggest that PDT-DC vaccination is more effective than conventional DC therapy for the treatment of cancers.
树突状细胞 (DC) 介导的免疫疗法对大多数实体瘤的疗效并不如预期。本研究证明了通过负载光动力疗法 (PDT) 诱导的肿瘤裂解物的 DC 介导的针对实体瘤的免疫反应，其中包含热休克蛋白 (HSP) 70。PDT 肿瘤裂解物脉冲 DC (PDT-DC) 抑制乳腺 EMT6 肿瘤的生长程度大于冻融肿瘤裂解物脉冲 DC (FT-DC) 或 PDT 肿瘤裂解物。PDT-DC 对完全建立的 (即晚期) 实体瘤也显示出显著的抗肿瘤作用。综上所述，这些结果表明，与传统的 DC 治疗相比，PDT-DC 疫苗接种在癌症治疗方面更有效。
