Tan Liuchang, Shen Xiaoxiao, He Zhiqiang, Lu Yuangang
Department of Plastic Surgery, Daping Hospital, Army Medical University, Chongqing, China.
Front Oncol. 2022 May 27;12:863107. doi: 10.3389/fonc.2022.863107. eCollection 2022.
Cancer is a major threat to human health because of its high mortality, easy recurrence, strong invasion, and metastasis. Photodynamic therapy (PDT) is a promising minimally invasive treatment for tumor. Compared with traditional treatment methods, PDT is less invasive and does not easily damage normal tissues. Most of the effects of this treatment are due to the direct effects of singlet oxygen together with reactive oxygen species. PDT can provide the source of active oxygen for the Fenton reaction, which enhances ferroptosis and also improves the efficacy of PDT in antitumor therapy. Additionally, in contrast to chemotherapy and radiotherapy, PDT has the effect of stimulating the immune response, which can effectively induce immunogenic cell death (ICD) and stimulate immunity. PDT is an ideal minimally invasive treatment method for tumors. In this paper, according to the characteristics of anti-tumor immunity of PDT, some tumor treatment strategies of PDT combined with anti-tumor immunotherapy are reviewed.
癌症因其高死亡率、易复发、强侵袭性和转移性而成为对人类健康的重大威胁。光动力疗法（PDT）是一种很有前景的肿瘤微创治疗方法。与传统治疗方法相比，PDT的侵入性较小，不易损伤正常组织。这种治疗的大部分效果归因于单线态氧与活性氧物质的直接作用。PDT可以为芬顿反应提供活性氧来源，增强铁死亡，还能提高PDT在抗肿瘤治疗中的疗效。此外，与化疗和放疗不同，PDT具有刺激免疫反应的作用，可有效诱导免疫原性细胞死亡（ICD）并刺激免疫力。PDT是一种理想的肿瘤微创治疗方法。本文根据PDT的抗肿瘤免疫特性，综述了一些PDT联合抗肿瘤免疫治疗的肿瘤治疗策略。
