Cardiovascular Department, Chinese PLA General Hospital, Beijing, China.
J Renin Angiotensin Aldosterone Syst. 2012 Dec;13(4):420-5. doi: 10.1177/1470320312444745. Epub 2012 May 3.
Resistin, an adipocyte-derived hormone, was found to be linked to metabolic syndrome and insulin resistance over the past decade. There is growing evidence that resistin plays a potential role in endothelial dysfunction. To the best of our knowledge, few studies have been concerned with the effect of resistin on endothelial function in a Tibetan population.
To investigate the correlation of resistin and endothelial function among preclinical Tibetan male young adults.
All participants recruited were young adults between 30 and 40 years old of male gender in Lhasa city. All subjects were native Tibetan. A total of 90 healthy subjects were accepted after excluding hypertension, diabetes, hyperlipidemia or coronary artery disease. The subjects were divided into three groups according to flow-mediated dilation (FMD): lower FMD (group A), intermediate FMD (group B) and higher FMD (group C). Body mass index, systolic blood pressure (SBP), diastolic blood pressure (DBP) and cigarette smoking were evaluated. Venous blood was sampled for the measurement of lipid profile, fasting blood glucose (FBG), fasting insulin (FINS), endothelin-1 (ET-1) and plasma resistin quantitation. The non-invasive vascular endothelial function was evaluated through the measurement of FMD with B-mode ultrasound. The insulin resistance was estimated as homeostatic model assessment of insulin resistance (HOMA-IR) = FINS(mu/L)*FBG(mmol/L)/22.5.
No statistical significance was found between groups in age, smoking, SBP, DBP, fasting insulin, total cholesterol and HOMA-IR (p>0.05). In the lipid profile, high density lipoprotein (HDL) and low density lipoprotein (LDL) cholesterol in group C were better than in groups A and B (p<0.01). Body mass index, which is an indicator for obesity, was much lower in group C than in group A and B (p<0.05 and 0.01 respectively). Comparison of plasma resistin concentrations: group A > group B > group C (p<0.01). Comparison of plasma ET-1 concentrations had a similar result: group A > group B > group C (p<0.05). The multivariate regression analysis showed that total cholesterol (p<0.05), LDL cholesterol (p<0.01), plasma resistin (p<0.01) and plasma ET-1 (p<0.01) were correlated with FMD.
Resistin is involved in endothelial dysfunction in preclinical male young Tibetan adults.
在过去的十年中，人们发现抵抗素是一种脂肪细胞衍生的激素，与代谢综合征和胰岛素抵抗有关。越来越多的证据表明抵抗素在血管内皮功能障碍中发挥潜在作用。据我们所知，很少有研究关注抵抗素对藏族人群内皮功能的影响。
探讨西藏地区男性青年人群中抵抗素与内皮功能的相关性。
所有纳入的参与者均为拉萨市 30 至 40 岁的男性青年。所有受试者均为藏族人。共纳入 90 例健康受试者，排除高血压、糖尿病、高脂血症或冠心病。根据血流介导的扩张（FMD）将受试者分为三组：低 FMD 组（A 组）、中 FMD 组（B 组）和高 FMD 组（C 组）。评估体重指数、收缩压（SBP）、舒张压（DBP）和吸烟情况。抽取静脉血检测血脂谱、空腹血糖（FBG）、空腹胰岛素（FINS）、内皮素-1（ET-1）和血浆抵抗素定量。采用 B 型超声测量 FMD 评估非侵入性血管内皮功能。胰岛素抵抗采用稳态模型评估胰岛素抵抗（HOMA-IR）=FINS（μL）*FBG（mmol/L）/22.5 进行估计。
三组间年龄、吸烟、SBP、DBP、空腹胰岛素、总胆固醇和 HOMA-IR 无统计学差异（p>0.05）。在血脂谱中，C 组的高密度脂蛋白（HDL）和低密度脂蛋白（LDL）胆固醇优于 A 组和 B 组（p<0.01）。C 组的体重指数（肥胖的一个指标）明显低于 A 组和 B 组（p<0.05 和 0.01）。血浆抵抗素浓度比较：A 组>B 组>C 组（p<0.01）。血浆 ET-1 浓度比较也有类似结果：A 组>B 组>C 组（p<0.05）。多元回归分析显示，总胆固醇（p<0.05）、LDL 胆固醇（p<0.01）、血浆抵抗素（p<0.01）和血浆 ET-1（p<0.01）与 FMD 相关。
抵抗素参与了西藏地区男性青年人群的内皮功能障碍。
