siRNA 在果蝇 X 染色体剂量补偿中的作用。
A role for siRNA in X-chromosome dosage compensation in Drosophila melanogaster.
机构信息
Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA.
出版信息
Genetics. 2012 Jul;191(3):1023-8. doi: 10.1534/genetics.112.140236. Epub 2012 May 2.
Abstract
Sex-chromosome dosage compensation requires selective identification of X chromatin. How this occurs is not fully understood. We show that small interfering RNA (siRNA) mutations enhance the lethality of Drosophila males deficient in X recognition and partially rescue females that inappropriately dosage-compensate. Our findings are consistent with a role for siRNA in selective recognition of X chromatin.
摘要
性染色体剂量补偿需要选择性识别 X 染色体。目前尚不完全清楚这是如何发生的。我们表明，小干扰 RNA（siRNA）突变增强了果蝇雄性中 X 识别缺陷的致死性，并部分挽救了不适当剂量补偿的雌性。我们的发现与 siRNA 在 X 染色体选择性识别中的作用一致。
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