Fiorito S
Dipartimento di Medicina Clinica, Universita' Sapienza di Roma, Roma, Italia.
Clin Ter. 2012;163(2):155-8.
Engineered nanomaterials are increasingly being used for commercial purposes and especially for biomedical and biotechnological applications. Carbon nanotubes in particular are viewed as a class of nanomaterials with high potential for biological applications due to their unique mechanical, physical and chemical properties. Carbon nanotubes are cylindrical molecules composed solely of carbon atoms. They can be thought of as a seamless cylinder formed from a graphitic sheet with a hexagonal lattice structure. The CNT ends resemble hemispherical buckyballs connected by a graphene cylinder. The properties of individual CNTs vary depending on their atomic structure. Upon their discovery, the extraordinary properties have made CNTs the focus of a wide spectrum of research topics with potential for development into viable commercial applications. Carbon nanotubes are the most promising new nanoparticles that can be used for drug and gene delivery. Among numerous potential applications, including DNA and protein sensors, in vitro cell markers, diagnostic imaging contrast agents, the use of these carbon-nanostructures as multifunctional biological transporters, agents for selective cancer destruction and drug and gene delivery systems has been explored. Moreover, various cell types have been shown to grow extremely well on C-nanotubes, giving a potential for applications such as scaffolds and structures/coatings for tissue regeneration/repair.
工程纳米材料正越来越多地用于商业目的,尤其是生物医学和生物技术应用。由于其独特的机械、物理和化学性质,碳纳米管尤其被视为一类具有巨大生物应用潜力的纳米材料。碳纳米管是仅由碳原子组成的圆柱形分子。它们可以被看作是由具有六边形晶格结构的石墨片形成的无缝圆柱体。碳纳米管的末端类似于由石墨烯圆柱体连接的半球形巴基球。单个碳纳米管的性质因其原子结构而异。自发现以来,其非凡的性质使碳纳米管成为众多研究课题的焦点,有望发展成为可行的商业应用。碳纳米管是最有前途的新型纳米颗粒,可用于药物和基因递送。在众多潜在应用中,包括DNA和蛋白质传感器、体外细胞标记物、诊断成像造影剂等,人们已经探索了将这些碳纳米结构用作多功能生物转运体、选择性癌症破坏剂以及药物和基因递送系统。此外,各种细胞类型已被证明在碳纳米管上生长得非常好,这为组织再生/修复的支架和结构/涂层等应用提供了潜力。