Hooymans P M, Janknegt R, Lohman J J
Department of Clinical Pharmacy, Maasland Hospital, Sittard, The Netherlands.
Pharm Weekbl Sci. 1990 Oct 19;12(5):188-9. doi: 10.1007/BF01980044.
The sorption of clonazepam to polyvinyl chloride tubing, polyethylene-coated tubing and to a polyethylene syringe was determined. Pumping of clonazepam (5 mg/48 ml) through the polyvinyl chloride tubing with flow rates of 2 ml/h and 4 ml/h resulted in a reduction of the clonazepam concentration to about 40% and 55% of the original strength after 0.6 h, respectively. This value was 55% at a flow rate of 2 ml/h and a clonazepam concentration of 10 mg/48 ml. The effluent clonazepam concentration increased gradually after an infusion period of 1 h. Sorption of clonazepam to the polyethylene syringe and to the tubing coated on the inside with polyethylene does not occur. The use of polyethylene-coated administration sets is recommended for intravenous administration of clonazepam.
测定了氯硝西泮在聚氯乙烯管材、聚乙烯涂层管材以及聚乙烯注射器上的吸附情况。以2 ml/h和4 ml/h的流速将氯硝西泮（5 mg/48 ml）泵入聚氯乙烯管材，0.6小时后，氯硝西泮浓度分别降至原来浓度的约40%和55%。当流速为2 ml/h且氯硝西泮浓度为10 mg/48 ml时，该值为55%。输注1小时后，流出液中氯硝西泮浓度逐渐升高。氯硝西泮不会吸附在聚乙烯注射器以及内部涂有聚乙烯的管材上。建议使用聚乙烯涂层给药装置进行氯硝西泮的静脉给药。
