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黄芩苷诱导 C17.2 神经干细胞分化的 DNA 微阵列表达分析。

DNA microarray expression analysis of baicalin-induced differentiation of C17.2 neural stem cells.

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China (CUHK), Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, P. R. China.

出版信息

Chembiochem. 2012 Jun 18;13(9):1286-90. doi: 10.1002/cbic.201200145. Epub 2012 May 3.

DOI:10.1002/cbic.201200145
PMID:22556041
Abstract

Identifying baicalin-regulated genes for neuronal differentiation: Baicalin is a potent neuronal-differentiation-inducing compound. This study explored the gene expression regulated through baicalin-induced differentiation of C17.2 neural stem cells by using a DNA microarray followed by qPCR validation. The expression of 15 genes was significantly regulated among the 58 differentially expressed genes important for nervous system development and function.

摘要

鉴定黄芩素调控神经元分化的基因

黄芩素是一种有效的神经元诱导分化化合物。本研究通过 DNA 微阵列分析和 qPCR 验证，探讨了黄芩素诱导 C17.2 神经干细胞分化过程中基因表达的变化。在对神经系统发育和功能重要的 58 个差异表达基因中，有 15 个基因的表达发生了显著调节。

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