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黄芩苷调节干细胞作为治疗更年期综合征的一个创新点。

Baicalin regulates stem cells as a creative point in the treatment of climacteric syndrome.

作者信息

Wei Qian, Hao Xia, Lau Benson Wui-Man, Wang Shaoxia, Li Yue

机构信息

State Key Laboratory of Component-Based Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, Hong Kong SAR, China.

出版信息

Front Pharmacol. 2022 Nov 2;13:986436. doi: 10.3389/fphar.2022.986436. eCollection 2022.

DOI:10.3389/fphar.2022.986436
PMID:36408261
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9666758/
Abstract

It is widely acknowledged that the climacteric syndrome negatively affects women's quality of life and leads to cerebral ischemic injury, osteoporosis and cardiovascular disease. One of the main active ingredients in Radix Scutellariae, Baicalin, has been established to possess a wide range of pharmacological effects and is beneficial in enhancing osteogenic differentiation and cardiovascular disease. Baicalin's profound metabolic impact on various stem cell populations and their fate specification could improve the efficiency of stem cell therapy for climacteric syndrome. However, Baicalin-mediated processes are complex and many of the underlying mechanisms are not fully fathomed yet. This review aims to shed light on the regulatory role of Baicalin on the diverse behaviors of distinct stem cell populations and provide a good cell source for stem cell therapy to broaden the therapeutic landscape for climacteric syndrome patients.

摘要

众所周知，更年期综合征会对女性生活质量产生负面影响，并导致脑缺血损伤、骨质疏松和心血管疾病。黄芩的主要活性成分之一黄芩苷已被证实具有广泛的药理作用，有助于增强成骨分化和改善心血管疾病。黄芩苷对各种干细胞群体及其命运决定具有深远的代谢影响，这可能会提高更年期综合征干细胞治疗的效率。然而，黄芩苷介导的过程很复杂，许多潜在机制尚未完全阐明。本综述旨在阐明黄芩苷对不同干细胞群体多种行为的调节作用，为干细胞治疗提供良好的细胞来源，以拓宽更年期综合征患者的治疗前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a867/9666758/64942da72d06/fphar-13-986436-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a867/9666758/a08465ee7ce1/FPHAR_fphar-2022-986436_wc_abs.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a867/9666758/433c4db388c2/fphar-13-986436-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a867/9666758/0bb5ed6e8376/fphar-13-986436-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a867/9666758/f34e0567798f/fphar-13-986436-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a867/9666758/2a8fcb588e3c/fphar-13-986436-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a867/9666758/64942da72d06/fphar-13-986436-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a867/9666758/a08465ee7ce1/FPHAR_fphar-2022-986436_wc_abs.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a867/9666758/433c4db388c2/fphar-13-986436-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a867/9666758/0bb5ed6e8376/fphar-13-986436-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a867/9666758/0751867351a6/fphar-13-986436-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a867/9666758/f34e0567798f/fphar-13-986436-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a867/9666758/2a8fcb588e3c/fphar-13-986436-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a867/9666758/64942da72d06/fphar-13-986436-g006.jpg

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3
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