Department of Medical Biochemistry, University of Madras, Taramani Campus, Chennai, 600 113, India.
Inflammopharmacology. 2013 Feb;21(1):47-53. doi: 10.1007/s10787-012-0136-6. Epub 2012 May 4.
Semecarpus anacardium Linn. nut milk extract (SA) was evaluated for its antidiabetic role in type 2 diabetic rats. Type 2 diabetes was induced in rats by feeding high-fat diet for 2 weeks followed by single intraperitoneal injection of streptozotocin 35 mg/kg body weight. Diabetic rats were treated with SA orally at a dosage of 200 mg/kg body weight daily for 30 days. Metformin (500 mg/kg body weight, orally) was used as a reference drug. SA significantly (p < 0.05) reduced the blood glucose levels and decreased the levels of HbA1c and the glucose intolerance. SA treatment significantly (p < 0.05) decreased the increase in lipid profile. The levels of urea, uric acid and creatinine were restored to near normal levels when compared with control diabetic rats. The histopathological abnormalities were also found to be normalized after treatment with SA nut milk extract. The potential antihyperglycemic action of SA is plausibly due to its underlying antioxidant role.
腰果坚果奶提取物（SA）在 2 型糖尿病大鼠中具有抗糖尿病作用，对此进行了评估。通过给大鼠喂食高脂肪饮食 2 周，然后单次腹腔内注射链脲佐菌素 35 mg/kg 体重，诱导 2 型糖尿病。糖尿病大鼠每日口服 SA 200mg/kg 体重，连续 30 天。二甲双胍（500mg/kg 体重，口服）用作参考药物。SA 可显著（p<0.05）降低血糖水平，降低 HbA1c 和葡萄糖耐量水平。SA 治疗可显著（p<0.05）降低血脂谱的升高。与对照糖尿病大鼠相比，尿素、尿酸和肌酐水平恢复到接近正常水平。经 SA 坚果奶提取物治疗后，组织病理学异常也得到了正常化。SA 的潜在降血糖作用可能与其潜在的抗氧化作用有关。
